Matches in SemOpenAlex for { <https://semopenalex.org/work/W3175266235> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W3175266235 abstract "Certain enteric pathogens stably establish themselves within host cells because they have evolved mechanisms to evade elimination. For example, the intracellular pathogen Salmonella secretes the AvrA protein which has potent suppressive effects on innate immune and apoptotic pathways. To determine the mechanism by which AvrA mediates these effects, we created transgenic Drosophila harboring avrA, allowing directed expression of AvrA in Drosophila tissues. We show that AvrA has potent and specific inhibitory activity against the JNK pathway in Drosophila and in cultured mammalian cells. Intriguingly, we also found that AvrA expression in a background of constitutive JNK pathway activation resulted in increased proliferation of Drosophila tissue whereas AvrA expression in a wild type background did not. Furthermore, reporter gene assays in cultured cells showed AvrA mediated inhibition of constitutive JNK pathway activation resulted in increased ERK signaling. We also show that the mechanism by which AvrA mediates JNK pathway inhibition is via the acetylation of the activation loop threonine of MKK4 - a residue necessarily phosphorylated during activation of this enzyme. Together, these studies show Salmonella has evolved a protein that inhibits the pro-apoptotic JNK pathway, with the secondary effect of dysregulating normal tissue growth. Research funding provided by Burroughs Welcome Fund." @default.
- W3175266235 created "2021-07-05" @default.
- W3175266235 creator A5035732255 @default.
- W3175266235 creator A5057779997 @default.
- W3175266235 creator A5062449195 @default.
- W3175266235 creator A5078257803 @default.
- W3175266235 date "2008-03-01" @default.
- W3175266235 modified "2023-09-23" @default.
- W3175266235 title "Modulation of host apoptotic signaling by the Salmonella effector protein AvrA" @default.
- W3175266235 doi "https://doi.org/10.1096/fasebj.22.1_supplement.320.5" @default.
- W3175266235 hasPublicationYear "2008" @default.
- W3175266235 type Work @default.
- W3175266235 sameAs 3175266235 @default.
- W3175266235 citedByCount "0" @default.
- W3175266235 crossrefType "journal-article" @default.
- W3175266235 hasAuthorship W3175266235A5035732255 @default.
- W3175266235 hasAuthorship W3175266235A5057779997 @default.
- W3175266235 hasAuthorship W3175266235A5062449195 @default.
- W3175266235 hasAuthorship W3175266235A5078257803 @default.
- W3175266235 hasConcept C104317684 @default.
- W3175266235 hasConcept C11960822 @default.
- W3175266235 hasConcept C136449434 @default.
- W3175266235 hasConcept C150194340 @default.
- W3175266235 hasConcept C161733203 @default.
- W3175266235 hasConcept C184235292 @default.
- W3175266235 hasConcept C51785407 @default.
- W3175266235 hasConcept C54355233 @default.
- W3175266235 hasConcept C55493867 @default.
- W3175266235 hasConcept C57074206 @default.
- W3175266235 hasConcept C62478195 @default.
- W3175266235 hasConcept C86803240 @default.
- W3175266235 hasConcept C8891405 @default.
- W3175266235 hasConcept C95444343 @default.
- W3175266235 hasConcept C97029542 @default.
- W3175266235 hasConceptScore W3175266235C104317684 @default.
- W3175266235 hasConceptScore W3175266235C11960822 @default.
- W3175266235 hasConceptScore W3175266235C136449434 @default.
- W3175266235 hasConceptScore W3175266235C150194340 @default.
- W3175266235 hasConceptScore W3175266235C161733203 @default.
- W3175266235 hasConceptScore W3175266235C184235292 @default.
- W3175266235 hasConceptScore W3175266235C51785407 @default.
- W3175266235 hasConceptScore W3175266235C54355233 @default.
- W3175266235 hasConceptScore W3175266235C55493867 @default.
- W3175266235 hasConceptScore W3175266235C57074206 @default.
- W3175266235 hasConceptScore W3175266235C62478195 @default.
- W3175266235 hasConceptScore W3175266235C86803240 @default.
- W3175266235 hasConceptScore W3175266235C8891405 @default.
- W3175266235 hasConceptScore W3175266235C95444343 @default.
- W3175266235 hasConceptScore W3175266235C97029542 @default.
- W3175266235 hasIssue "S1" @default.
- W3175266235 hasLocation W31752662351 @default.
- W3175266235 hasOpenAccess W3175266235 @default.
- W3175266235 hasPrimaryLocation W31752662351 @default.
- W3175266235 hasRelatedWork W2004726042 @default.
- W3175266235 hasRelatedWork W2010932108 @default.
- W3175266235 hasRelatedWork W2015725807 @default.
- W3175266235 hasRelatedWork W2081246372 @default.
- W3175266235 hasRelatedWork W2091587849 @default.
- W3175266235 hasRelatedWork W2381340599 @default.
- W3175266235 hasRelatedWork W2384817912 @default.
- W3175266235 hasRelatedWork W2805781019 @default.
- W3175266235 hasRelatedWork W3035328115 @default.
- W3175266235 hasRelatedWork W4254421120 @default.
- W3175266235 hasVolume "22" @default.
- W3175266235 isParatext "false" @default.
- W3175266235 isRetracted "false" @default.
- W3175266235 magId "3175266235" @default.
- W3175266235 workType "article" @default.