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- W3175267773 endingPage "6770" @default.
- W3175267773 startingPage "6770" @default.
- W3175267773 abstract "Aim: we aimed to construct a bioinformatics-based co-regulatory network of mRNAs and non coding RNAs (ncRNAs), which is implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), followed by its validation in a NAFLD animal model. Materials and Methods: The mRNAs–miRNAs–lncRNAs regulatory network involved in NAFLD was retrieved and constructed utilizing bioinformatics tools. Then, we validated this network using an NAFLD animal model, high sucrose and high fat diet (HSHF)-fed rats. Finally, the expression level of the network players was assessed in the liver tissues using reverse transcriptase real-time polymerase chain reaction. Results: in-silico constructed network revealed six mRNAs (YAP1, FOXA2, AMOTL2, TEAD2, SMAD4 and NF2), two miRNAs (miR-650 and miR-1205), and two lncRNAs (RPARP-AS1 and SRD5A3-AS1) that play important roles as a co-regulatory network in NAFLD pathogenesis. Moreover, the expression level of these constructed network–players was significantly different between NAFLD and normal control. Conclusion and future perspectives: this study provides new insight into the molecular mechanism of NAFLD pathogenesis and valuable clues for the potential use of the constructed RNA network in effective diagnostic or management strategies of NAFLD." @default.
- W3175267773 created "2021-07-05" @default.
- W3175267773 creator A5001360519 @default.
- W3175267773 creator A5001885273 @default.
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- W3175267773 creator A5063132082 @default.
- W3175267773 creator A5083792019 @default.
- W3175267773 creator A5091052652 @default.
- W3175267773 date "2021-06-24" @default.
- W3175267773 modified "2023-09-26" @default.
- W3175267773 title "mRNA-miRNA-lncRNA Regulatory Network in Nonalcoholic Fatty Liver Disease" @default.
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- W3175267773 doi "https://doi.org/10.3390/ijms22136770" @default.
- W3175267773 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8269036" @default.
- W3175267773 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34202571" @default.
- W3175267773 hasPublicationYear "2021" @default.