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- W3175276431 endingPage "7093" @default.
- W3175276431 startingPage "7093" @default.
- W3175276431 abstract "Chronic myeloid leukemia (CML) is a classical example of stem cell cancer since it arises in a multipotent hematopoietic stem cell upon the acquisition of the t(9;22) chromosomal translocation, that converts it into a leukemic stem cell (LSC). The resulting BCR-ABL1 fusion gene encodes a deregulated tyrosine kinase that is recognized as the disease driver. Therapy with tyrosine kinase inhibitors (TKIs) eliminates progenitor and more differentiated cells but fails to eradicate quiescent LSCs. Thus, although many patients obtain excellent responses and a proportion of them can even attempt treatment discontinuation (treatment free remission [TFR]) after some years of therapy, LSCs persist, and represent a potentially dangerous reservoir feeding relapse and hampering TFR. Over the past two decades, intensive efforts have been devoted to the characterization of CML LSCs and to the dissection of the cell-intrinsic and -extrinsic mechanisms sustaining their persistence, in an attempt to find druggable targets enabling LSC eradication. Here we provide an overview and an update on these mechanisms, focusing in particular on the most recent acquisitions. Moreover, we provide a critical appraisal of the clinical relevance and feasibility of LSC targeting in CML." @default.
- W3175276431 created "2021-07-05" @default.
- W3175276431 creator A5014181214 @default.
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- W3175276431 creator A5045537458 @default.
- W3175276431 creator A5074800679 @default.
- W3175276431 creator A5086909836 @default.
- W3175276431 date "2021-06-30" @default.
- W3175276431 modified "2023-10-18" @default.
- W3175276431 title "Targeting Leukemic Stem Cells in Chronic Myeloid Leukemia: Is It Worth the Effort?" @default.
- W3175276431 cites W120597284 @default.
- W3175276431 cites W126560450 @default.
- W3175276431 cites W1572714088 @default.
- W3175276431 cites W1597813032 @default.
- W3175276431 cites W1599349966 @default.
- W3175276431 cites W1699860439 @default.
- W3175276431 cites W1918052277 @default.
- W3175276431 cites W1966722003 @default.
- W3175276431 cites W1968655578 @default.
- W3175276431 cites W1968747503 @default.
- W3175276431 cites W1968933286 @default.
- W3175276431 cites W1970504379 @default.
- W3175276431 cites W1974182237 @default.
- W3175276431 cites W1979050260 @default.
- W3175276431 cites W1982401508 @default.
- W3175276431 cites W1987180287 @default.
- W3175276431 cites W1987239635 @default.
- W3175276431 cites W1991692801 @default.
- W3175276431 cites W1992382947 @default.
- W3175276431 cites W1995091371 @default.
- W3175276431 cites W1995940184 @default.
- W3175276431 cites W1996982049 @default.
- W3175276431 cites W1997254819 @default.
- W3175276431 cites W2004821524 @default.
- W3175276431 cites W2006711239 @default.
- W3175276431 cites W2013225336 @default.
- W3175276431 cites W2018279800 @default.
- W3175276431 cites W2021635600 @default.
- W3175276431 cites W2023853595 @default.
- W3175276431 cites W2024290860 @default.
- W3175276431 cites W2027638186 @default.
- W3175276431 cites W2030444151 @default.
- W3175276431 cites W2035287163 @default.
- W3175276431 cites W2036318987 @default.
- W3175276431 cites W2036987278 @default.
- W3175276431 cites W2037837200 @default.
- W3175276431 cites W2043332526 @default.
- W3175276431 cites W2050184823 @default.
- W3175276431 cites W2054103222 @default.
- W3175276431 cites W2062166095 @default.
- W3175276431 cites W2063582323 @default.
- W3175276431 cites W2067200597 @default.
- W3175276431 cites W2068753140 @default.
- W3175276431 cites W2071534620 @default.
- W3175276431 cites W2078555565 @default.
- W3175276431 cites W2081491982 @default.
- W3175276431 cites W2081813128 @default.
- W3175276431 cites W2090817847 @default.
- W3175276431 cites W2094155177 @default.
- W3175276431 cites W2096882254 @default.
- W3175276431 cites W2107503279 @default.
- W3175276431 cites W2110471949 @default.
- W3175276431 cites W2110774869 @default.
- W3175276431 cites W2112810605 @default.
- W3175276431 cites W2112817157 @default.
- W3175276431 cites W2117356576 @default.
- W3175276431 cites W2118453722 @default.
- W3175276431 cites W2120517971 @default.
- W3175276431 cites W2122224021 @default.
- W3175276431 cites W2124068666 @default.
- W3175276431 cites W2124097332 @default.
- W3175276431 cites W2128172115 @default.
- W3175276431 cites W2128175263 @default.
- W3175276431 cites W2134234801 @default.
- W3175276431 cites W2136331786 @default.
- W3175276431 cites W2141256843 @default.
- W3175276431 cites W2142135918 @default.
- W3175276431 cites W2150873649 @default.
- W3175276431 cites W2171358244 @default.
- W3175276431 cites W2177783313 @default.
- W3175276431 cites W2195303060 @default.
- W3175276431 cites W2257567845 @default.
- W3175276431 cites W2259238188 @default.
- W3175276431 cites W2304385408 @default.
- W3175276431 cites W2329659524 @default.
- W3175276431 cites W2343680173 @default.
- W3175276431 cites W2345368403 @default.
- W3175276431 cites W2347071589 @default.
- W3175276431 cites W2410092046 @default.
- W3175276431 cites W2412914653 @default.
- W3175276431 cites W2473480037 @default.
- W3175276431 cites W2516246505 @default.
- W3175276431 cites W2519666751 @default.
- W3175276431 cites W2520339276 @default.
- W3175276431 cites W2558610261 @default.
- W3175276431 cites W2565130792 @default.
- W3175276431 cites W2580232087 @default.
- W3175276431 cites W2590311184 @default.