Matches in SemOpenAlex for { <https://semopenalex.org/work/W3175290423> ?p ?o ?g. }
- W3175290423 endingPage "113839" @default.
- W3175290423 startingPage "113839" @default.
- W3175290423 abstract "Neurokinin B (NKB) plays a pivotal role in the regulation of reproduction in vertebrates. However, whether this neuropeptide is dispensable for reproduction in teleosts remains unknown. In order to reveal its authentic functions in fish, in this study, two tachykinin 3 (tac3) genes encoding Nkbs were functional mutated in zebrafish using the Transcription Activator-like Effector Nucleases (TALEN) technology. We established tac3a-/-, tac3b-/- and tac3a-/-;tac3b-/- mutant lines, and investigated their reproductive performance and ontogeny. According to our study, spermatogenesis and folliculogenesis were not impaired in tac3a-/-, tac3b-/- and tac3a-/-;tac3b-/- mutant lines, but changes in the expression of genes related to reproductive axis were observed after loss of Tac3, suggesting that possible compensatory response was activated to maintained the reproductive function in zebrafish. In summary, our results indicate that mutation of tac3 genes do not disrupt the reproduction in zebrafish unlike in mammals, revealing the plasticity of reproductive neuroendocrine system in the brain of zebrafish." @default.
- W3175290423 created "2021-07-05" @default.
- W3175290423 creator A5015480789 @default.
- W3175290423 creator A5017560653 @default.
- W3175290423 creator A5018073672 @default.
- W3175290423 creator A5041583830 @default.
- W3175290423 creator A5064222660 @default.
- W3175290423 creator A5083589773 @default.
- W3175290423 date "2021-09-01" @default.
- W3175290423 modified "2023-09-27" @default.
- W3175290423 title "Knockout of tac3 genes in zebrafish shows no impairment of reproduction" @default.
- W3175290423 cites W1515156296 @default.
- W3175290423 cites W1964782601 @default.
- W3175290423 cites W1966841534 @default.
- W3175290423 cites W1972602091 @default.
- W3175290423 cites W1972940909 @default.
- W3175290423 cites W1980556586 @default.
- W3175290423 cites W1992041715 @default.
- W3175290423 cites W1997471206 @default.
- W3175290423 cites W2000097985 @default.
- W3175290423 cites W2010920434 @default.
- W3175290423 cites W2025295789 @default.
- W3175290423 cites W2029110222 @default.
- W3175290423 cites W2029503919 @default.
- W3175290423 cites W2030585597 @default.
- W3175290423 cites W2032770360 @default.
- W3175290423 cites W2036907328 @default.
- W3175290423 cites W2057829363 @default.
- W3175290423 cites W2071664293 @default.
- W3175290423 cites W2081114661 @default.
- W3175290423 cites W2081196218 @default.
- W3175290423 cites W2098360503 @default.
- W3175290423 cites W2101031400 @default.
- W3175290423 cites W2107912962 @default.
- W3175290423 cites W2128150894 @default.
- W3175290423 cites W2133007496 @default.
- W3175290423 cites W2142686356 @default.
- W3175290423 cites W2143506157 @default.
- W3175290423 cites W2165992477 @default.
- W3175290423 cites W2174306973 @default.
- W3175290423 cites W2266093504 @default.
- W3175290423 cites W2461364696 @default.
- W3175290423 cites W2469843389 @default.
- W3175290423 cites W2597564736 @default.
- W3175290423 cites W2789360440 @default.
- W3175290423 cites W2792864344 @default.
- W3175290423 cites W2793470973 @default.
- W3175290423 cites W2796099474 @default.
- W3175290423 cites W2801482770 @default.
- W3175290423 cites W2947826281 @default.
- W3175290423 cites W2961303544 @default.
- W3175290423 cites W3004983222 @default.
- W3175290423 cites W3014706241 @default.
- W3175290423 cites W3030978076 @default.
- W3175290423 cites W3032374457 @default.
- W3175290423 doi "https://doi.org/10.1016/j.ygcen.2021.113839" @default.
- W3175290423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34181932" @default.
- W3175290423 hasPublicationYear "2021" @default.
- W3175290423 type Work @default.
- W3175290423 sameAs 3175290423 @default.
- W3175290423 citedByCount "4" @default.
- W3175290423 countsByYear W31752904232022 @default.
- W3175290423 countsByYear W31752904232023 @default.
- W3175290423 crossrefType "journal-article" @default.
- W3175290423 hasAuthorship W3175290423A5015480789 @default.
- W3175290423 hasAuthorship W3175290423A5017560653 @default.
- W3175290423 hasAuthorship W3175290423A5018073672 @default.
- W3175290423 hasAuthorship W3175290423A5041583830 @default.
- W3175290423 hasAuthorship W3175290423A5064222660 @default.
- W3175290423 hasAuthorship W3175290423A5083589773 @default.
- W3175290423 hasConcept C104317684 @default.
- W3175290423 hasConcept C141231307 @default.
- W3175290423 hasConcept C143065580 @default.
- W3175290423 hasConcept C144501496 @default.
- W3175290423 hasConcept C170493617 @default.
- W3175290423 hasConcept C2776808119 @default.
- W3175290423 hasConcept C2776878037 @default.
- W3175290423 hasConcept C31909778 @default.
- W3175290423 hasConcept C51785407 @default.
- W3175290423 hasConcept C54355233 @default.
- W3175290423 hasConcept C86803240 @default.
- W3175290423 hasConcept C88045685 @default.
- W3175290423 hasConcept C95444343 @default.
- W3175290423 hasConceptScore W3175290423C104317684 @default.
- W3175290423 hasConceptScore W3175290423C141231307 @default.
- W3175290423 hasConceptScore W3175290423C143065580 @default.
- W3175290423 hasConceptScore W3175290423C144501496 @default.
- W3175290423 hasConceptScore W3175290423C170493617 @default.
- W3175290423 hasConceptScore W3175290423C2776808119 @default.
- W3175290423 hasConceptScore W3175290423C2776878037 @default.
- W3175290423 hasConceptScore W3175290423C31909778 @default.
- W3175290423 hasConceptScore W3175290423C51785407 @default.
- W3175290423 hasConceptScore W3175290423C54355233 @default.
- W3175290423 hasConceptScore W3175290423C86803240 @default.
- W3175290423 hasConceptScore W3175290423C88045685 @default.
- W3175290423 hasConceptScore W3175290423C95444343 @default.
- W3175290423 hasLocation W31752904231 @default.
- W3175290423 hasLocation W31752904232 @default.