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- W3175295510 abstract "PPARG, a ligand-activated transcription factor plays a critical role in regulation of blood pressure and vascular function. We hypothesized that smooth muscle PPARG protects against hypertension and resistance vessel dysfunction. Mice expressing dominant negative PPARG (S-P467L) in smooth muscle or non-transgenic control (NT) were implanted with DOCA-salt and allowed ad lib. 0.15 M NaCl for 21 days in addition to chow and tap water. Blood pressure was monitored by telemetry and mesenteric arterial function was assessed by pressurized myograph. At baseline, 24-hour mean arterial pressure (MAP) was similar between NT and S-P467L mice, while the transgenic mice were tachycardic. DOCA-salt increased MAP in all animals, but S-P467L mice exhibited increased sensitivity (Δ mmHg; S-P467L n=5, +34.2±7.3 p=0.003 vs baseline; NT n=3, +15.0±8.5 p=0.152 vs baseline). Heart rate was similarly decreased in both groups after DOCA-salt. Vasorelaxation to acetylcholine was impaired in S-P467L mesenteric arteries compared to NT at baseline and this effect was further exaggerated after DOCA salt. Vasopressin-induced constriction was significantly reduced in S-P467L compared to NT arteries after DOCA-salt, but the response to KCl and endothelin-1 did not differ between groups. We conclude that impaired smooth muscle PPARG sensitizes the effects of DOCA-salt induced hypertension and vascular dysfunction." @default.
- W3175295510 created "2021-07-05" @default.
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- W3175295510 date "2013-04-01" @default.
- W3175295510 modified "2023-09-25" @default.
- W3175295510 title "Deoxycorticosterone acetate (DOCA)‐salt exacerbates hypertension and vascular dysfunction in mice expressing dominant negative Peroxisome Proliferator‐Activated Receptor‐gamma (PPARG) in smooth muscle" @default.
- W3175295510 doi "https://doi.org/10.1096/fasebj.27.1_supplement.708.10" @default.
- W3175295510 hasPublicationYear "2013" @default.
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