FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3175320976> ?p ?o ?g. }

• W3175320976 endingPage "3166" @default.
• W3175320976 startingPage "3166" @default.
• W3175320976 abstract "Administering preoperative radiochemotherapy (RCT) in stage II-III tumors to locally advanced rectal carcinoma patients has proved to be effective in a high percentage of cases. Despite this, 20–30% of patients show no response or even disease progression. At present, preoperative response is assessed by a combination of imaging and tumor regression on histopathology, but recent studies suggest that various genetic abnormalities may be associated with the sensitivity or resistance of rectal cancer tumor cells to neoadjuvant therapy. In the present study we investigated the relationship between genetic lesions detected by high-density single-nucleotide polymorphisms (SNP) arrays 6.0 and response to neoadjuvant RCT, evaluated according to Dworak criteria in 39 rectal cancer tumors before treatment. The highest frequency of copy-number (CN) losses detected corresponded to chromosomes 18q (n = 27; 69%), 1p (n = 22; 56%), 15q (n = 19; 49%), 8p (n = 18; 48%), 4q (n = 17; 46%), and 22q (n = 17; 46%); in turn, CN gains more frequently involved chromosomes 20p (n = 22; 56%), 8p (n = 20; 51%), and 15q (n = 16; 41%). There was a significant association between alterations in the 1p, 3q, 7q, 12p, 17q, 20p, and 22q chromosomal regions and the degree of response to therapy prior to surgery. However, 4q, 15q11.1, and 15q14 chromosomal region alterations were identified as important by five prediction algorithms, i.e., those with the greatest influence on predicting the tumor response to treatment with preoperative RCT. Multivariate analysis of prognostic factors showed that gains on 15q11.1 and carcinoembryonic antigen (CEA) levels serum at diagnosis were the only independent variables predicting disease-free survival (DFS). Lymph node involvement also showed a prognostic impact on overall survival (OS) in the multivariate analysis. A deep-learning-based algorithm showed a 100% success rate in predicting both DFS and OS at 60 months after diagnosis of the disease. In summary, our results indicate the existence of an association between tumor genetic abnormalities at diagnosis, response to neoadjuvant therapy, and survival of patients with locally advanced rectal cancer. In addition to the clinical and biological characteristics of locally advanced rectal cancer patients, these could be used in the future as therapeutic and prognostic biomarkers, to identify patients sensitive or resistant to preoperative treatment, helping guide therapeutic decision-making. Additional prospective studies in larger series of patients are required to confirm the clinical utility of the newly identified biomarkers." @default.
• W3175320976 created "2021-07-05" @default.
• W3175320976 creator A5004453681 @default.
• W3175320976 creator A5018488368 @default.
• W3175320976 creator A5021025819 @default.
• W3175320976 creator A5026013029 @default.
• W3175320976 creator A5028232531 @default.
• W3175320976 creator A5047068506 @default.
• W3175320976 creator A5065497666 @default.
• W3175320976 creator A5066129214 @default.
• W3175320976 creator A5067351937 @default.
• W3175320976 creator A5075795532 @default.
• W3175320976 creator A5080152510 @default.
• W3175320976 creator A5090056802 @default.
• W3175320976 date "2021-06-24" @default.
• W3175320976 modified "2023-10-16" @default.
• W3175320976 title "High-Risk Clinicopathological and Genetic Features and Outcomes in Patients Receiving Neoadjuvant Radiochemotherapy for Locally Advanced Rectal Cancer" @default.
• W3175320976 cites W1631467871 @default.
• W3175320976 cites W1795468129 @default.
• W3175320976 cites W1964532421 @default.
• W3175320976 cites W2016747856 @default.
• W3175320976 cites W2024352246 @default.
• W3175320976 cites W2025855986 @default.
• W3175320976 cites W2061106441 @default.
• W3175320976 cites W2065100534 @default.
• W3175320976 cites W2076789869 @default.
• W3175320976 cites W2092152677 @default.
• W3175320976 cites W2124695217 @default.
• W3175320976 cites W2125452425 @default.
• W3175320976 cites W2126201018 @default.
• W3175320976 cites W2128502368 @default.
• W3175320976 cites W2136543046 @default.
• W3175320976 cites W2139248078 @default.
• W3175320976 cites W2144922697 @default.
• W3175320976 cites W2156665896 @default.
• W3175320976 cites W2159344928 @default.
• W3175320976 cites W2159919969 @default.
• W3175320976 cites W2165352267 @default.
• W3175320976 cites W2181164912 @default.
• W3175320976 cites W2329231635 @default.
• W3175320976 cites W2330944574 @default.
• W3175320976 cites W2331742925 @default.
• W3175320976 cites W2352578155 @default.
• W3175320976 cites W2414160094 @default.
• W3175320976 cites W2528569464 @default.
• W3175320976 cites W2558796542 @default.
• W3175320976 cites W2761319459 @default.
• W3175320976 cites W2762032476 @default.
• W3175320976 cites W2769868522 @default.
• W3175320976 cites W2786388608 @default.
• W3175320976 cites W2807150061 @default.
• W3175320976 cites W2955159354 @default.
• W3175320976 cites W2973139180 @default.
• W3175320976 cites W2976897973 @default.
• W3175320976 cites W3000472238 @default.
• W3175320976 cites W3025690127 @default.
• W3175320976 cites W3035922473 @default.
• W3175320976 cites W3049048287 @default.
• W3175320976 cites W3083805389 @default.
• W3175320976 cites W3089078724 @default.
• W3175320976 cites W3092536668 @default.
• W3175320976 cites W3111609153 @default.
• W3175320976 cites W3120158178 @default.
• W3175320976 cites W3126532109 @default.
• W3175320976 cites W3126583483 @default.
• W3175320976 cites W3132562907 @default.
• W3175320976 cites W3162318140 @default.
• W3175320976 cites W4246977463 @default.
• W3175320976 cites W4320800276 @default.
• W3175320976 doi "https://doi.org/10.3390/cancers13133166" @default.
• W3175320976 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8269103" @default.
• W3175320976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34202891" @default.
• W3175320976 hasPublicationYear "2021" @default.
• W3175320976 type Work @default.
• W3175320976 sameAs 3175320976 @default.
• W3175320976 citedByCount "3" @default.
• W3175320976 countsByYear W31753209762022 @default.
• W3175320976 countsByYear W31753209762023 @default.
• W3175320976 crossrefType "journal-article" @default.
• W3175320976 hasAuthorship W3175320976A5004453681 @default.
• W3175320976 hasAuthorship W3175320976A5018488368 @default.
• W3175320976 hasAuthorship W3175320976A5021025819 @default.
• W3175320976 hasAuthorship W3175320976A5026013029 @default.
• W3175320976 hasAuthorship W3175320976A5028232531 @default.
• W3175320976 hasAuthorship W3175320976A5047068506 @default.
• W3175320976 hasAuthorship W3175320976A5065497666 @default.
• W3175320976 hasAuthorship W3175320976A5066129214 @default.
• W3175320976 hasAuthorship W3175320976A5067351937 @default.
• W3175320976 hasAuthorship W3175320976A5075795532 @default.
• W3175320976 hasAuthorship W3175320976A5080152510 @default.
• W3175320976 hasAuthorship W3175320976A5090056802 @default.
• W3175320976 hasBestOaLocation W31753209761 @default.
• W3175320976 hasConcept C104317684 @default.
• W3175320976 hasConcept C121608353 @default.
• W3175320976 hasConcept C126322002 @default.
• W3175320976 hasConcept C135763542 @default.
• W3175320976 hasConcept C139275648 @default.
• W3175320976 hasConcept C142724271 @default.

• next