Matches in SemOpenAlex for { <https://semopenalex.org/work/W3175341024> ?p ?o ?g. }
- W3175341024 endingPage "109364" @default.
- W3175341024 startingPage "109364" @default.
- W3175341024 abstract "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) variants govern transmissibility, responsiveness to vaccination, and disease severity. In a screen for new models of SARS-CoV-2 infection, we identify human H522 lung adenocarcinoma cells as naturally permissive to SARS-CoV-2 infection despite complete absence of angiotensin-converting enzyme 2 (ACE2) expression. Remarkably, H522 infection requires the E484D S variant; viruses expressing wild-type S are not infectious. Anti-S monoclonal antibodies differentially neutralize SARS-CoV-2 E484D S in H522 cells as compared to ACE2-expressing cells. Sera from vaccinated individuals block this alternative entry mechanism, whereas convalescent sera are less effective. Although the H522 receptor remains unknown, depletion of surface heparan sulfates block H522 infection. Temporally resolved transcriptomic and proteomic profiling reveal alterations in cell cycle and the antiviral host cell response, including MDA5-dependent activation of type I interferon signaling. These findings establish an alternative SARS-CoV-2 host cell receptor for the E484D SARS-CoV-2 variant, which may impact tropism of SARS-CoV-2 and consequently human disease pathogenesis." @default.
- W3175341024 created "2021-07-05" @default.
- W3175341024 creator A5003959534 @default.
- W3175341024 creator A5009590962 @default.
- W3175341024 creator A5011235227 @default.
- W3175341024 creator A5012065860 @default.
- W3175341024 creator A5012289981 @default.
- W3175341024 creator A5020285725 @default.
- W3175341024 creator A5022681560 @default.
- W3175341024 creator A5022711103 @default.
- W3175341024 creator A5023947283 @default.
- W3175341024 creator A5024399532 @default.
- W3175341024 creator A5024660037 @default.
- W3175341024 creator A5031090086 @default.
- W3175341024 creator A5035720803 @default.
- W3175341024 creator A5036038306 @default.
- W3175341024 creator A5036335582 @default.
- W3175341024 creator A5041931203 @default.
- W3175341024 creator A5042066808 @default.
- W3175341024 creator A5042724430 @default.
- W3175341024 creator A5043825862 @default.
- W3175341024 creator A5049080246 @default.
- W3175341024 creator A5055422337 @default.
- W3175341024 creator A5070153307 @default.
- W3175341024 creator A5077537679 @default.
- W3175341024 creator A5077992307 @default.
- W3175341024 creator A5083026464 @default.
- W3175341024 creator A5084174098 @default.
- W3175341024 creator A5084515990 @default.
- W3175341024 creator A5085441966 @default.
- W3175341024 creator A5087993365 @default.
- W3175341024 creator A5089479264 @default.
- W3175341024 date "2021-07-01" @default.
- W3175341024 modified "2023-10-18" @default.
- W3175341024 title "Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell" @default.
- W3175341024 cites W1539248632 @default.
- W3175341024 cites W1544561280 @default.
- W3175341024 cites W1550814250 @default.
- W3175341024 cites W1605500799 @default.
- W3175341024 cites W1974963408 @default.
- W3175341024 cites W1995495646 @default.
- W3175341024 cites W2004829503 @default.
- W3175341024 cites W2010457001 @default.
- W3175341024 cites W2024438817 @default.
- W3175341024 cites W2035618305 @default.
- W3175341024 cites W2048508099 @default.
- W3175341024 cites W2049887006 @default.
- W3175341024 cites W2049923099 @default.
- W3175341024 cites W2050709903 @default.
- W3175341024 cites W2053186308 @default.
- W3175341024 cites W2064350446 @default.
- W3175341024 cites W2071680235 @default.
- W3175341024 cites W2086347780 @default.
- W3175341024 cites W2095148741 @default.
- W3175341024 cites W2100278600 @default.
- W3175341024 cites W2104617152 @default.
- W3175341024 cites W2114104545 @default.
- W3175341024 cites W2115462905 @default.
- W3175341024 cites W2124777268 @default.
- W3175341024 cites W2127372263 @default.
- W3175341024 cites W2134972446 @default.
- W3175341024 cites W2144206275 @default.
- W3175341024 cites W2146512944 @default.
- W3175341024 cites W2150409982 @default.
- W3175341024 cites W2152936822 @default.
- W3175341024 cites W2156095183 @default.
- W3175341024 cites W2157391239 @default.
- W3175341024 cites W2158131682 @default.
- W3175341024 cites W2164988816 @default.
- W3175341024 cites W2165070219 @default.
- W3175341024 cites W2167384912 @default.
- W3175341024 cites W2197124664 @default.
- W3175341024 cites W2214074259 @default.
- W3175341024 cites W2298105916 @default.
- W3175341024 cites W2518706921 @default.
- W3175341024 cites W2544360569 @default.
- W3175341024 cites W2592811885 @default.
- W3175341024 cites W2755284350 @default.
- W3175341024 cites W2770180107 @default.
- W3175341024 cites W2785205047 @default.
- W3175341024 cites W2790740760 @default.
- W3175341024 cites W2857722519 @default.
- W3175341024 cites W2903201721 @default.
- W3175341024 cites W2907797562 @default.
- W3175341024 cites W2912436263 @default.
- W3175341024 cites W2936804536 @default.
- W3175341024 cites W2947642275 @default.
- W3175341024 cites W2948622157 @default.
- W3175341024 cites W2950973961 @default.
- W3175341024 cites W2978726586 @default.
- W3175341024 cites W2995902735 @default.
- W3175341024 cites W3001118548 @default.
- W3175341024 cites W3003217347 @default.
- W3175341024 cites W3004280078 @default.
- W3175341024 cites W3004919484 @default.
- W3175341024 cites W3007223608 @default.
- W3175341024 cites W3007643904 @default.
- W3175341024 cites W3008028633 @default.