FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3175357830> ?p ?o ?g. }

• W3175357830 endingPage "261.e6" @default.
• W3175357830 startingPage "252" @default.
• W3175357830 abstract "Patients with Mendelian susceptibility to mycobacterial disease (MSMD) experience recurrent and/or persistent infectious diseases associated with poorly virulent mycobacteria. Multifocal osteomyelitis is among the representative manifestations of MSMD. The frequency of multifocal osteomyelitis is especially high in patients with MSMD etiologies that impair cellular response to IFN-γ, such as IFN-γR1, IFN-γR2, or STAT1 deficiency.This study sought to characterize the mechanism underlying multifocal osteomyelitis in MSMD.GM colonies prepared from bone marrow mononuclear cells from patients with autosomal dominant (AD) IFN-γR1 deficiency, AD STAT1 deficiency, or STAT1 gain of function (GOF) and from healthy controls were differentiated into osteoclasts in the presence or absence of IFN-γ. The inhibitory effect of IFN-γ on osteoclastogenesis was investigated by quantitative PCR, immunoblotting, tartrate-resistant acid phosphatase staining, and pit formation assays.Increased osteoclast numbers were identified by examining the histopathology of osteomyelitis in patients with AD IFN-γR1 deficiency or AD STAT1 deficiency. In the presence of receptor activator of nuclear factor kappa-B ligand and M-CSF, GM colonies from patients with AD IFN-γR1 deficiency, AD STAT1 deficiency, or STAT1 GOF differentiated into osteoclasts, similar to GM colonies from healthy volunteers. IFN-γ concentration-dependent inhibition of osteoclast formation was impaired in GM colonies from patients with AD IFN-γR1 deficiency or AD STAT1 deficiency, whereas it was enhanced in GM colonies from patients with STAT1 GOF.Osteoclast differentiation is increased in AD IFN-γR1 deficiency and AD STAT1 deficiency due to an impaired response to IFN-γ, leading to excessive osteoclast proliferation and, by inference, increased bone resorption in infected foci, which may underlie multifocal osteomyelitis." @default.
• W3175357830 created "2021-07-05" @default.
• W3175357830 creator A5001297615 @default.
• W3175357830 creator A5027300481 @default.
• W3175357830 creator A5030970846 @default.
• W3175357830 creator A5044937567 @default.
• W3175357830 creator A5046928386 @default.
• W3175357830 creator A5050547712 @default.
• W3175357830 creator A5062976742 @default.
• W3175357830 creator A5074314811 @default.
• W3175357830 creator A5082345026 @default.
• W3175357830 creator A5087814317 @default.
• W3175357830 date "2022-01-01" @default.
• W3175357830 modified "2023-10-16" @default.
• W3175357830 title "Enhanced osteoclastogenesis in patients with MSMD due to impaired response to IFN-γ" @default.
• W3175357830 cites W1489825629 @default.
• W3175357830 cites W1549053710 @default.
• W3175357830 cites W1553429135 @default.
• W3175357830 cites W160560928 @default.
• W3175357830 cites W1639854378 @default.
• W3175357830 cites W1827723601 @default.
• W3175357830 cites W1963605778 @default.
• W3175357830 cites W1973241546 @default.
• W3175357830 cites W1973575404 @default.
• W3175357830 cites W1975818868 @default.
• W3175357830 cites W1976309520 @default.
• W3175357830 cites W1981038069 @default.
• W3175357830 cites W1990029516 @default.
• W3175357830 cites W1995218602 @default.
• W3175357830 cites W1995225418 @default.
• W3175357830 cites W1998058239 @default.
• W3175357830 cites W1998612079 @default.
• W3175357830 cites W2000706836 @default.
• W3175357830 cites W2004192405 @default.
• W3175357830 cites W2012198904 @default.
• W3175357830 cites W2012776873 @default.
• W3175357830 cites W2013286665 @default.
• W3175357830 cites W2015190484 @default.
• W3175357830 cites W2017372504 @default.
• W3175357830 cites W2018656610 @default.
• W3175357830 cites W2034779553 @default.
• W3175357830 cites W2036368043 @default.
• W3175357830 cites W2038424276 @default.
• W3175357830 cites W2043901802 @default.
• W3175357830 cites W2045356817 @default.
• W3175357830 cites W2049234640 @default.
• W3175357830 cites W2050242791 @default.
• W3175357830 cites W2056107229 @default.
• W3175357830 cites W2056532039 @default.
• W3175357830 cites W2057284367 @default.
• W3175357830 cites W2058935084 @default.
• W3175357830 cites W2060047278 @default.
• W3175357830 cites W2061286588 @default.
• W3175357830 cites W2064683151 @default.
• W3175357830 cites W2066609936 @default.
• W3175357830 cites W2066806053 @default.
• W3175357830 cites W2067612747 @default.
• W3175357830 cites W2073822142 @default.
• W3175357830 cites W2074390096 @default.
• W3175357830 cites W2075482744 @default.
• W3175357830 cites W2076382804 @default.
• W3175357830 cites W2085600062 @default.
• W3175357830 cites W2086216226 @default.
• W3175357830 cites W2093252878 @default.
• W3175357830 cites W2094575986 @default.
• W3175357830 cites W2095127782 @default.
• W3175357830 cites W2095961369 @default.
• W3175357830 cites W2103333716 @default.
• W3175357830 cites W2103433909 @default.
• W3175357830 cites W2104866075 @default.
• W3175357830 cites W2107427053 @default.
• W3175357830 cites W2109630291 @default.
• W3175357830 cites W2114751633 @default.
• W3175357830 cites W2116521901 @default.
• W3175357830 cites W2119049249 @default.
• W3175357830 cites W2122919633 @default.
• W3175357830 cites W2128708639 @default.
• W3175357830 cites W2129954532 @default.
• W3175357830 cites W2131418107 @default.
• W3175357830 cites W2132541910 @default.
• W3175357830 cites W2135254713 @default.
• W3175357830 cites W2140600672 @default.
• W3175357830 cites W2144280353 @default.
• W3175357830 cites W2149827038 @default.
• W3175357830 cites W2150285359 @default.
• W3175357830 cites W2152309124 @default.
• W3175357830 cites W2153570621 @default.
• W3175357830 cites W2154218327 @default.
• W3175357830 cites W2157376708 @default.
• W3175357830 cites W2161825631 @default.
• W3175357830 cites W2163667076 @default.
• W3175357830 cites W2164308544 @default.
• W3175357830 cites W2171382646 @default.
• W3175357830 cites W2229027714 @default.
• W3175357830 cites W2256879069 @default.
• W3175357830 cites W2300983099 @default.
• W3175357830 cites W2321271436 @default.
• W3175357830 cites W2337579752 @default.

• next