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- W3175363038 endingPage "2070" @default.
- W3175363038 startingPage "2053" @default.
- W3175363038 abstract "The incidence of human immunodeficiency virus-1 (HIV-1) associated meningitis has been declining in the post-combination antiretroviral treatment (ART) era, although survival rates remain low for the common causes like tuberculosis and cryptococcal disease. Diagnosis and treatment of meningitis in HIV-1 is complicated by atypical clinical presentations, limited accuracy of diagnostic tests, access to diagnostic tests, and therapeutic agents in low- and middle-income countries (LMIC) and immune reconstitution inflammatory syndrome (IRIS).We provide an overview of the common etiologies of meningitis in HIV-1-infected adults, suggest a diagnostic approach based on readily available tests, and review specific chemotherapeutic agents, host-directed therapies, supportive care, timing of ART initiation, and considerations in the management of IRIS with a focus on resource-limited settings. They identify key knowledge gaps and suggest areas for future research.Evidence-based management of HIV-1-associated meningitis is sparse for common etiologies. More readily available and sensitive diagnostic tests as well as standardized investigation strategies are required in LMIC. There is a lack of availability of recommended drugs in areas of high HIV-1 prevalence and a limited pipeline of novel chemotherapeutic agents. Host-directed therapies have been inadequately studied." @default.
- W3175363038 created "2021-07-05" @default.
- W3175363038 creator A5003971032 @default.
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- W3175363038 creator A5029089921 @default.
- W3175363038 creator A5077892502 @default.
- W3175363038 creator A5090394540 @default.
- W3175363038 date "2021-06-21" @default.
- W3175363038 modified "2023-09-26" @default.
- W3175363038 title "Strategies for the diagnosis and management of meningitis in HIV-infected adults in resource limited settings" @default.
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