Matches in SemOpenAlex for { <https://semopenalex.org/work/W3175389384> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W3175389384 abstract "Influenza strain diversity and variability and individual immune health contribute to reduced vaccine efficacy. Among adjuvants that enhance vaccine effectiveness, several studies have examined the relationship between acute exercise stress and influenza vaccination immune responses in humans. It is proposed that acute bouts of stress enhance immune response, but optimal intervention, timing of intervention, and mechanisms have yet to be identified. As Toll-like receptor (TLR) agonists enhance innate immune responses and support development of chronic humoral responses, exercise induced release of the TLR4 ligand lipopolysaccharide (LPS) into circulation may be a mechanism for benefit of pre-vaccine exercise. This study aimed to assess the effects of exercise and exercise-heat stress completed before seasonal influenza vaccination (IV) on short- and long-term immune responses. Thirty-four males (body mass, 77.41±12.48kg; age, 21.5±4.4y; maximal aerobic capacity (VO2max), 43.53±8.24mL/kg/min) were randomized into 1 of 3 groups: no exercise (NE, n=12) or 60 minutes of 60%VO2max exercise with (MEH, n=11) or without (ME, n=11) environmental heat stress. Exercise and baseline blood samples were completed 25.11±5.92h before IV, and subsequent blood samples were collected 23.45±6.13h, 13.06±2.96d, and 29.54±3.73d following IV. Exercise environmental conditions were different between ME and MEH, respectively (average wet bulb globe temperature, 32.91±2.67°C, 41.21±2.88°C; p<0.001), but physiological stress was similar (average rectal temperature, 37.30±0.48°C, 27.61±1.36°C, p=0.513; heart rate, 114±105bpm, 118±105bpm, p=0.103) due to controlled exercise intensity. On-going research will utilize hemagglutinin inhibition, cortisol, and LPS assays to quantify virus-specific antibody responses, stress, and TLR4 activation respectively. Understanding innate and humoral responses will elucidate the potential of exercise and exercise-heat stressors as adjuvants for IV. Support or Funding Information New investigator start-up, InCHIP Interdisciplinary Seed Grant This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal." @default.
- W3175389384 created "2021-07-05" @default.
- W3175389384 creator A5006497801 @default.
- W3175389384 creator A5020363323 @default.
- W3175389384 creator A5021759915 @default.
- W3175389384 creator A5026953166 @default.
- W3175389384 creator A5043664169 @default.
- W3175389384 creator A5058787843 @default.
- W3175389384 creator A5062441968 @default.
- W3175389384 creator A5063634399 @default.
- W3175389384 creator A5071791611 @default.
- W3175389384 creator A5084902135 @default.
- W3175389384 date "2018-04-01" @default.
- W3175389384 modified "2023-09-26" @default.
- W3175389384 title "Aerobic Exercise and Environmental Heat Stress as Adjuvants to Seasonal Influenza Vaccine" @default.
- W3175389384 doi "https://doi.org/10.1096/fasebj.2018.32.1_supplement.lb255" @default.
- W3175389384 hasPublicationYear "2018" @default.
- W3175389384 type Work @default.
- W3175389384 sameAs 3175389384 @default.
- W3175389384 citedByCount "0" @default.
- W3175389384 crossrefType "journal-article" @default.
- W3175389384 hasAuthorship W3175389384A5006497801 @default.
- W3175389384 hasAuthorship W3175389384A5020363323 @default.
- W3175389384 hasAuthorship W3175389384A5021759915 @default.
- W3175389384 hasAuthorship W3175389384A5026953166 @default.
- W3175389384 hasAuthorship W3175389384A5043664169 @default.
- W3175389384 hasAuthorship W3175389384A5058787843 @default.
- W3175389384 hasAuthorship W3175389384A5062441968 @default.
- W3175389384 hasAuthorship W3175389384A5063634399 @default.
- W3175389384 hasAuthorship W3175389384A5071791611 @default.
- W3175389384 hasAuthorship W3175389384A5084902135 @default.
- W3175389384 hasConcept C103038586 @default.
- W3175389384 hasConcept C126322002 @default.
- W3175389384 hasConcept C203014093 @default.
- W3175389384 hasConcept C22070199 @default.
- W3175389384 hasConcept C2779134260 @default.
- W3175389384 hasConcept C2780689484 @default.
- W3175389384 hasConcept C3008058167 @default.
- W3175389384 hasConcept C3018751465 @default.
- W3175389384 hasConcept C524204448 @default.
- W3175389384 hasConcept C71924100 @default.
- W3175389384 hasConcept C8891405 @default.
- W3175389384 hasConceptScore W3175389384C103038586 @default.
- W3175389384 hasConceptScore W3175389384C126322002 @default.
- W3175389384 hasConceptScore W3175389384C203014093 @default.
- W3175389384 hasConceptScore W3175389384C22070199 @default.
- W3175389384 hasConceptScore W3175389384C2779134260 @default.
- W3175389384 hasConceptScore W3175389384C2780689484 @default.
- W3175389384 hasConceptScore W3175389384C3008058167 @default.
- W3175389384 hasConceptScore W3175389384C3018751465 @default.
- W3175389384 hasConceptScore W3175389384C524204448 @default.
- W3175389384 hasConceptScore W3175389384C71924100 @default.
- W3175389384 hasConceptScore W3175389384C8891405 @default.
- W3175389384 hasIssue "S1" @default.
- W3175389384 hasLocation W31753893841 @default.
- W3175389384 hasOpenAccess W3175389384 @default.
- W3175389384 hasPrimaryLocation W31753893841 @default.
- W3175389384 hasRelatedWork W155301942 @default.
- W3175389384 hasRelatedWork W2019574320 @default.
- W3175389384 hasRelatedWork W2078461378 @default.
- W3175389384 hasRelatedWork W2143941734 @default.
- W3175389384 hasRelatedWork W2610793451 @default.
- W3175389384 hasRelatedWork W3118529832 @default.
- W3175389384 hasRelatedWork W3132683572 @default.
- W3175389384 hasRelatedWork W3193012584 @default.
- W3175389384 hasRelatedWork W4206914007 @default.
- W3175389384 hasRelatedWork W4221063257 @default.
- W3175389384 hasVolume "32" @default.
- W3175389384 isParatext "false" @default.
- W3175389384 isRetracted "false" @default.
- W3175389384 magId "3175389384" @default.
- W3175389384 workType "article" @default.