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- W3175396386 abstract "Tryptophan hydroxylase 1 (TPH1) is the limiting enzyme for peripheral serotonin synthesis. Expression of TPH1 by valve interstitial cells (VIC) could implicate an autocrine serotonin signaling mechanism in the pathogenesis of myxomatous valve disease (MVD). The study objectives were to: 1) determine expression of TPH1 in canine and human myxomatous mitral valves, and 2) identify VIC phenotype expressing TPH1. METHODS Expression of TPH1 was determined by immunoblot (IB) and immunofluorescence microscopy (IFM). TPH1 expression was co-localized with markers of VIC phenotype transformation; α-smooth muscle actin (α-SMA) and embryonic non-muscle myosin (SMemb). RESULTS Canine and human myxomatous mitral valves strongly expressed TPH1 on IB and IFM analyses. α-SMA and SMemb exhibited distinctly different expression patterns that were similar in canine and human myxomatous valves. TPH1 expression co-localized with SMemb+ phenotype VIC, but not α-SMA+ phenotype VIC. CONCLUSIONS TPH1 expression by canine and human myxomatous mitral valves implicates autocrine serotonin signaling in the pathogenesis of MVD. TPH1 expression is associated with VIC phenotype transformation. Autocrine serotonin signaling could form the basis of a unifying hypothesis for the pathogenesis of spontaneous MVD and serotonergic drug-induced valvulopathy. Research supported by the Heart to Heart foundation." @default.
- W3175396386 created "2021-07-05" @default.
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- W3175396386 date "2009-04-01" @default.
- W3175396386 modified "2023-09-26" @default.
- W3175396386 title "Phenotype‐transformed interstitial cells in canine and human myxomatous mitral valves express tryptophan hydroxylase 1" @default.
- W3175396386 doi "https://doi.org/10.1096/fasebj.23.1_supplement.362.12" @default.
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