FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3175438357> ?p ?o ?g. }

• W3175438357 abstract "Abstract Objective Uganda, like other African countries, has registered fewer COVID-19 cases and deaths per capita than non-African countries. The lower numbers of cases and deaths in Uganda might be due to pre-existing cross-immunity induced by zoonotic coronaviruses or circulating common cold human coronaviruses (HCoVs) before the COVID-19 pandemic. In order to test this premise, we compared IgA reactivity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and HCoVs in breast milk of US and rural Ugandan mothers collected in 2018 before the COVID-19 epidemic. Ugandan and US pre-pandemic breast milk samples were run in duplicate on enzyme-linked immunoadsorbent assay (ELISA) to measure specific IgA antibody reactivity to the spike proteins of SARS-CoV-2, human coronaviruses (HCoV) NL63, OC43, HKU1, and 229E. Pooled plasma from US COVID-19 positive and negative cases were employed as positive and negative controls, respectively. One Ugandan pre-pandemic milk sample had remarkably high reactivity against all HCoVs and SARS-CoV-2 spike proteins. There was higher IgA reactivity against the betacoronavirus HCoV-OC43 in Ugandan pre-pandemic milk samples by comparison with US pre-pandemic milk samples (p = 0.018). By contrast, there was significantly higher IgA reactivity against the alphacoronaviruses HCoV-229E and HCoV-NL63 in US pre-pandemic milk samples by comparison with Ugandan pre-pandemic milk samples (p < 0.0001 and 0.035, respectively). Conclusion Some Ugandan mothers may have robust pre-existing immunity against SARS-CoV-2 due to cross-immunity induced by HCoVs which may be passed on to their infants via breastfeeding. The differential pre-pandemic reactivity of US mothers to HCoV 229E and HCoV NL63 may have contributed to suboptimal antibody responses to SARS-CoV-2." @default.
• W3175438357 created "2021-07-05" @default.
• W3175438357 creator A5003467408 @default.
• W3175438357 creator A5033257648 @default.
• W3175438357 creator A5036599204 @default.
• W3175438357 creator A5047226069 @default.
• W3175438357 creator A5064110530 @default.
• W3175438357 creator A5065447693 @default.
• W3175438357 creator A5077590404 @default.
• W3175438357 date "2021-06-25" @default.
• W3175438357 modified "2023-09-27" @default.
• W3175438357 title "Differential pre-pandemic IgA reactivity against SARS-CoV-2 and circulating human coronaviruses measured in milk collected in Uganda and the USA" @default.
• W3175438357 cites W1905630967 @default.
• W3175438357 cites W1970244022 @default.
• W3175438357 cites W1992733618 @default.
• W3175438357 cites W2055431368 @default.
• W3175438357 cites W2109471081 @default.
• W3175438357 cites W2118336261 @default.
• W3175438357 cites W2135840694 @default.
• W3175438357 cites W2265898191 @default.
• W3175438357 cites W2605364764 @default.
• W3175438357 cites W2791745812 @default.
• W3175438357 cites W3016269138 @default.
• W3175438357 cites W3016900702 @default.
• W3175438357 cites W3025631553 @default.
• W3175438357 cites W3038872355 @default.
• W3175438357 cites W3046558543 @default.
• W3175438357 cites W3082647175 @default.
• W3175438357 cites W3084607431 @default.
• W3175438357 cites W3090049663 @default.
• W3175438357 cites W3091214020 @default.
• W3175438357 cites W3092050672 @default.
• W3175438357 cites W3096764372 @default.
• W3175438357 cites W3096867322 @default.
• W3175438357 cites W3098118792 @default.
• W3175438357 cites W3099989333 @default.
• W3175438357 cites W3109360305 @default.
• W3175438357 cites W3112389805 @default.
• W3175438357 cites W3113321715 @default.
• W3175438357 cites W3126265634 @default.
• W3175438357 cites W3126847903 @default.
• W3175438357 cites W3127200741 @default.
• W3175438357 cites W3128866689 @default.
• W3175438357 cites W3135333896 @default.
• W3175438357 cites W3135896629 @default.
• W3175438357 cites W3136200616 @default.
• W3175438357 cites W3145977403 @default.
• W3175438357 cites W3153692543 @default.
• W3175438357 cites W3154961073 @default.
• W3175438357 cites W3155604755 @default.
• W3175438357 cites W3163739433 @default.
• W3175438357 cites W4244698236 @default.
• W3175438357 doi "https://doi.org/10.1101/2021.06.24.21259294" @default.
• W3175438357 hasPublicationYear "2021" @default.
• W3175438357 type Work @default.
• W3175438357 sameAs 3175438357 @default.
• W3175438357 citedByCount "0" @default.
• W3175438357 crossrefType "posted-content" @default.
• W3175438357 hasAuthorship W3175438357A5003467408 @default.
• W3175438357 hasAuthorship W3175438357A5033257648 @default.
• W3175438357 hasAuthorship W3175438357A5036599204 @default.
• W3175438357 hasAuthorship W3175438357A5047226069 @default.
• W3175438357 hasAuthorship W3175438357A5064110530 @default.
• W3175438357 hasAuthorship W3175438357A5065447693 @default.
• W3175438357 hasAuthorship W3175438357A5077590404 @default.
• W3175438357 hasBestOaLocation W31754383571 @default.
• W3175438357 hasConcept C126322002 @default.
• W3175438357 hasConcept C159047783 @default.
• W3175438357 hasConcept C203014093 @default.
• W3175438357 hasConcept C2775871700 @default.
• W3175438357 hasConcept C2777648638 @default.
• W3175438357 hasConcept C2777691041 @default.
• W3175438357 hasConcept C2778137277 @default.
• W3175438357 hasConcept C2779134260 @default.
• W3175438357 hasConcept C2779341262 @default.
• W3175438357 hasConcept C3007834351 @default.
• W3175438357 hasConcept C3008058167 @default.
• W3175438357 hasConcept C524204448 @default.
• W3175438357 hasConcept C55493867 @default.
• W3175438357 hasConcept C71924100 @default.
• W3175438357 hasConcept C86803240 @default.
• W3175438357 hasConcept C8891405 @default.
• W3175438357 hasConcept C89623803 @default.
• W3175438357 hasConceptScore W3175438357C126322002 @default.
• W3175438357 hasConceptScore W3175438357C159047783 @default.
• W3175438357 hasConceptScore W3175438357C203014093 @default.
• W3175438357 hasConceptScore W3175438357C2775871700 @default.
• W3175438357 hasConceptScore W3175438357C2777648638 @default.
• W3175438357 hasConceptScore W3175438357C2777691041 @default.
• W3175438357 hasConceptScore W3175438357C2778137277 @default.
• W3175438357 hasConceptScore W3175438357C2779134260 @default.
• W3175438357 hasConceptScore W3175438357C2779341262 @default.
• W3175438357 hasConceptScore W3175438357C3007834351 @default.
• W3175438357 hasConceptScore W3175438357C3008058167 @default.
• W3175438357 hasConceptScore W3175438357C524204448 @default.
• W3175438357 hasConceptScore W3175438357C55493867 @default.
• W3175438357 hasConceptScore W3175438357C71924100 @default.
• W3175438357 hasConceptScore W3175438357C86803240 @default.
• W3175438357 hasConceptScore W3175438357C8891405 @default.
• W3175438357 hasConceptScore W3175438357C89623803 @default.

• next