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• W3175453934 abstract "It is well-established that anterior pituitary contains multiple endocrine cell populations, and each of them can secrete one/two hormone(s) to regulate vital physiological processes of vertebrates. However, the gene expression profiles of each pituitary cell population remains poorly characterized in most vertebrate groups. Here we analyzed the transcriptome of each cell population in adult chicken anterior pituitaries using single-cell RNA sequencing technology. The results showed that: (1) four out of five known endocrine cell clusters have been identified and designated as the lactotrophs, thyrotrophs, corticotrophs, and gonadotrophs, respectively. Somatotrophs were not analyzed in the current study. Each cell cluster can express at least one known endocrine hormone, and novel marker genes ( e.g., CD24 and HSPB1 in lactotrophs, NPBWR2 and NDRG1 in corticotrophs; DIO2 and SOUL in thyrotrophs, C5H11ORF96 and HPGDS in gonadotrophs) are identified. Interestingly, gonadotrophs were shown to abundantly express five peptide hormones: FSH, LH, GRP, CART and RLN3 ; (2) four non-endocrine/secretory cell types, including endothelial cells (expressing IGFBP7 and CFD ) and folliculo-stellate cells (FS-cells, expressing S100A6 and S100A10 ), were identified in chicken anterior pituitaries. Among them, FS-cells can express many growth factors, peptides ( e.g., WNT5A, HBEGF , Activins, VEGFC, NPY , and BMP4 ), and progenitor/stem cell-associated genes ( e.g. , Notch signaling components, CDH1 ), implying that the FS-cell cluster may act as a paracrine/autocrine signaling center and enrich pituitary progenitor/stem cells; (3) sexually dimorphic expression of many genes were identified in most cell clusters, including gonadotrophs and lactotrophs. Taken together, our data provides a bird’s-eye view on the diverse aspects of anterior pituitaries, including cell composition, heterogeneity, cell-to-cell communication, and gene expression profiles, which facilitates our comprehensive understanding of vertebrate pituitary biology." @default.
• W3175453934 created "2021-07-05" @default.
• W3175453934 creator A5006436200 @default.
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• W3175453934 creator A5064711465 @default.
• W3175453934 creator A5085963164 @default.
• W3175453934 creator A5087592842 @default.
• W3175453934 date "2021-06-29" @default.
• W3175453934 modified "2023-10-17" @default.
• W3175453934 title "Single-Cell RNA Sequencing Analysis of Chicken Anterior Pituitary: A Bird’s-Eye View on Vertebrate Pituitary" @default.
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