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- W3175458421 abstract "Nose is the only place where the brain “meets the outside world” and thus offers a huge window of opportunity to target a vast range of neurotherapeutics to the brain. Delivery of drugs to the brain especially via the nasal route requires a thorough understanding of various anatomical (nasal cavities, vestibules, olfactory, respiratory region, etc.) and physiological barriers (blood flow and lymphatic system, nasal valve and aerodynamics, mucociliary clearance, etc.) a drug has to surmount in nose, before it can successfully reach the target site. Besides these nasal barriers, in order to reach brain, additional barriers in brain, namely, blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB), further hinder the delivery of drugs in required concentration at the target site. The objective of this chapter is to provide a thorough understanding of these barriers’ properties in order to design an efficient drug delivery system that can efficiently overcome these hurdles." @default.
- W3175458421 created "2021-07-05" @default.
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- W3175458421 date "2021-01-01" @default.
- W3175458421 modified "2023-09-24" @default.
- W3175458421 title "An overview of anatomical and physiological aspects of the nose and the brain" @default.
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- W3175458421 doi "https://doi.org/10.1016/b978-0-12-822522-6.00029-1" @default.
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