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- W3175477149 endingPage "531" @default.
- W3175477149 startingPage "511" @default.
- W3175477149 abstract "Aging is by far the most prominent risk factor for Alzheimer's disease (AD), and both aging and AD are associated with apparent metabolic alterations. As developing effective therapeutic interventions to treat AD is clearly in urgent need, the impact of modulating whole-body and intracellular metabolism in preclinical models and in human patients, on disease pathogenesis, have been explored. There is also an increasing awareness of differential risk and potential targeting strategies related to biological sex, microbiome, and circadian regulation. As a major part of intracellular metabolism, mitochondrial bioenergetics, mitochondrial quality-control mechanisms, and mitochondria-linked inflammatory responses have been considered for AD therapeutic interventions. This review summarizes and highlights these efforts." @default.
- W3175477149 created "2021-07-05" @default.
- W3175477149 creator A5005935966 @default.
- W3175477149 creator A5025494373 @default.
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- W3175477149 creator A5062506120 @default.
- W3175477149 creator A5072500293 @default.
- W3175477149 creator A5073597792 @default.
- W3175477149 date "2022-02-01" @default.
- W3175477149 modified "2023-10-18" @default.
- W3175477149 title "Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease" @default.
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