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- W3175484857 abstract "Carcinoma of the thyroid gland is the most common malignancy exhibiting resistant to the available therapy. Thyroid carcinoma represents the fascinating model and particularly promising paradigm for targeted therapy because some of the key oncogenic events, activating mutations of genes coding for tyrosine kinases, occurring early in cancer development. Activating point mutation of B-RAF can occur early in the development of papillary carcinoma. Moreover, papillary carcinomas with these mutations have more aggressive properties. Phytochemicals exhibit strong antioxidant and antiproliferative activities, thus act as potential anti-cancer compounds. The virtual screening approach is adapted to screen phytochemicals against the B-RAF protein. The obtained results through in silico approach show better than current drugs sunitinib and sorafenib for B-RAF." @default.
- W3175484857 created "2021-07-05" @default.
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- W3175484857 date "2020-02-06" @default.
- W3175484857 modified "2023-09-25" @default.
- W3175484857 title "In Silico Approach for the Identification of Potential Phytochemical Inhibitors of B-RAF in Papillary Thyroid Cancer" @default.
- W3175484857 hasPublicationYear "2020" @default.
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