FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3175484920> ?p ?o ?g. }

• W3175484920 endingPage "196" @default.
• W3175484920 startingPage "192" @default.
• W3175484920 abstract "Fluoroquinolones are a family of broad spectrum, systemic antibacterial agents that have been used as therapy for infections in the respiratory and alimentary tract in animals. The pharmacodynamic of this class is widely described, predominantly to the commercial drugs ciprofloxacin (CIP), enrofloxacin (ENR), and pefloxacin (PEF). Bovine serum albumin (BSA) is the main endogenous carrier in the bovine bloodstream, being responsible for the biodistribution of different classes of molecules and drugs, including fluoroquinolones. The molecular features and interaction between BSA and fluoroquinolones are not fully described, thus, the present work enlightens the intimacy of the interaction of BSA with CIP, ENR, PEF through structural modeling and molecular docking calculation approaches. The role of key amino acid residues was assessed, indicating that the main protein binding pocket is composed by Trp-212 residue playing an important stabilization for the three fluoroquinolones through both hydrogen bonding and van der Waals forces, where reside the individual structural differences observed among the three fluoroquinolones and BSA. There is a descriptive protagonism of carboxyl group on the ENR interaction which traps the molecule and avoids the deep communication in the protein binding pocket, as well as the ligands CIP and PEF showed an interface amino acid residue interaction profile higher than 70%." @default.
• W3175484920 created "2021-07-05" @default.
• W3175484920 creator A5048696169 @default.
• W3175484920 creator A5069134264 @default.
• W3175484920 date "2021-06-30" @default.
• W3175484920 modified "2023-09-30" @default.
• W3175484920 title "Molecular docking analysis on the interaction between bovine serum albumin and three commercial fluoroquinolones: Ciprofloxacin, enrofloxacin and pefloxacin" @default.
• W3175484920 cites W1842770465 @default.
• W3175484920 cites W1971243838 @default.
• W3175484920 cites W1972317353 @default.
• W3175484920 cites W1973238993 @default.
• W3175484920 cites W1976770421 @default.
• W3175484920 cites W1978900536 @default.
• W3175484920 cites W1980619521 @default.
• W3175484920 cites W1985312497 @default.
• W3175484920 cites W1995666127 @default.
• W3175484920 cites W1996110829 @default.
• W3175484920 cites W2001864339 @default.
• W3175484920 cites W2004006450 @default.
• W3175484920 cites W2008373083 @default.
• W3175484920 cites W2016885538 @default.
• W3175484920 cites W2030730924 @default.
• W3175484920 cites W2032573343 @default.
• W3175484920 cites W2042089312 @default.
• W3175484920 cites W2043340061 @default.
• W3175484920 cites W2049830971 @default.
• W3175484920 cites W2050456292 @default.
• W3175484920 cites W2059897759 @default.
• W3175484920 cites W2068097632 @default.
• W3175484920 cites W2068301725 @default.
• W3175484920 cites W2078075907 @default.
• W3175484920 cites W2085221832 @default.
• W3175484920 cites W2092233638 @default.
• W3175484920 cites W2099468060 @default.
• W3175484920 cites W2125194413 @default.
• W3175484920 cites W2128981481 @default.
• W3175484920 cites W2129775766 @default.
• W3175484920 cites W2132121597 @default.
• W3175484920 cites W2170270376 @default.
• W3175484920 cites W2234329888 @default.
• W3175484920 cites W2342431205 @default.
• W3175484920 cites W2469988999 @default.
• W3175484920 cites W2520442286 @default.
• W3175484920 cites W2551113944 @default.
• W3175484920 cites W3120315443 @default.
• W3175484920 doi "https://doi.org/10.5155/eurjchem.12.2.192-196.2103" @default.
• W3175484920 hasPublicationYear "2021" @default.
• W3175484920 type Work @default.
• W3175484920 sameAs 3175484920 @default.
• W3175484920 citedByCount "2" @default.
• W3175484920 countsByYear W31754849202023 @default.
• W3175484920 crossrefType "journal-article" @default.
• W3175484920 hasAuthorship W3175484920A5048696169 @default.
• W3175484920 hasAuthorship W3175484920A5069134264 @default.
• W3175484920 hasBestOaLocation W31754849201 @default.
• W3175484920 hasConcept C112887158 @default.
• W3175484920 hasConcept C159110408 @default.
• W3175484920 hasConcept C178790620 @default.
• W3175484920 hasConcept C185592680 @default.
• W3175484920 hasConcept C21951064 @default.
• W3175484920 hasConcept C2778049240 @default.
• W3175484920 hasConcept C2778512257 @default.
• W3175484920 hasConcept C2778746504 @default.
• W3175484920 hasConcept C2779906673 @default.
• W3175484920 hasConcept C2781166304 @default.
• W3175484920 hasConcept C2781338088 @default.
• W3175484920 hasConcept C32909587 @default.
• W3175484920 hasConcept C41685203 @default.
• W3175484920 hasConcept C501593827 @default.
• W3175484920 hasConcept C55493867 @default.
• W3175484920 hasConcept C71240020 @default.
• W3175484920 hasConcept C71924100 @default.
• W3175484920 hasConcept C86807702 @default.
• W3175484920 hasConceptScore W3175484920C112887158 @default.
• W3175484920 hasConceptScore W3175484920C159110408 @default.
• W3175484920 hasConceptScore W3175484920C178790620 @default.
• W3175484920 hasConceptScore W3175484920C185592680 @default.
• W3175484920 hasConceptScore W3175484920C21951064 @default.
• W3175484920 hasConceptScore W3175484920C2778049240 @default.
• W3175484920 hasConceptScore W3175484920C2778512257 @default.
• W3175484920 hasConceptScore W3175484920C2778746504 @default.
• W3175484920 hasConceptScore W3175484920C2779906673 @default.
• W3175484920 hasConceptScore W3175484920C2781166304 @default.
• W3175484920 hasConceptScore W3175484920C2781338088 @default.
• W3175484920 hasConceptScore W3175484920C32909587 @default.
• W3175484920 hasConceptScore W3175484920C41685203 @default.
• W3175484920 hasConceptScore W3175484920C501593827 @default.
• W3175484920 hasConceptScore W3175484920C55493867 @default.
• W3175484920 hasConceptScore W3175484920C71240020 @default.
• W3175484920 hasConceptScore W3175484920C71924100 @default.
• W3175484920 hasConceptScore W3175484920C86807702 @default.
• W3175484920 hasIssue "2" @default.
• W3175484920 hasLocation W31754849201 @default.
• W3175484920 hasOpenAccess W3175484920 @default.
• W3175484920 hasPrimaryLocation W31754849201 @default.
• W3175484920 hasRelatedWork W1992334844 @default.
• W3175484920 hasRelatedWork W2087205436 @default.
• W3175484920 hasRelatedWork W2239269628 @default.

• next