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- W3175487560 abstract "Abstract Previously, we have identified a putative novel rapidly growing Mycobacterium species, referred to as TNTM28, recovered from the sputum of an apparently immunocompetent young man with an underlying pulmonary disease. Here we provide a thorough characterization of TNTM28 genome sequence, which consists of one chromosome of 5,526,191 bp with a 67.3% G + C content, and a total of 5193 predicted coding sequences. Phylogenomic analyses revealed a deep-rooting relationship to the Mycobacterium fortuitum complex, thus suggesting a new taxonomic entity. TNTM28 was predicted to be a human pathogen with a probability of 0.804, reflecting the identification of several virulence factors, including export systems (Sec, Tat, and ESX), a nearly complete set of Mce proteins, toxin-antitoxins systems, and an extended range of other genes involved in intramacrophage replication and persistence (hspX, ahpC, sodA, sodC, katG, mgtC, ClpR, virS, etc.), some of which had likely been acquired through horizontal gene transfer. Such an arsenal of potential virulence factors, along with an almost intact ESX-1 locus, might have significantly contributed to TNTM28 pathogenicity, as witnessed by its ability to replicate efficiently in macrophages. Overall, the identification of this new species as a potential human pathogen will help to broaden our understanding of mycobacterial pathogenesis." @default.
- W3175487560 created "2021-07-05" @default.
- W3175487560 creator A5039128760 @default.
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- W3175487560 date "2021-06-21" @default.
- W3175487560 modified "2023-09-25" @default.
- W3175487560 title "Phenotypic and genomic hallmarks of a novel, potentially pathogenic rapidly growing Mycobacterium species related to the Mycobacterium fortuitum complex" @default.
- W3175487560 cites W104710838 @default.
- W3175487560 cites W1904782847 @default.
- W3175487560 cites W1960952604 @default.
- W3175487560 cites W1969349373 @default.
- W3175487560 cites W1969919262 @default.
- W3175487560 cites W1980655268 @default.
- W3175487560 cites W1983261308 @default.
- W3175487560 cites W1983275536 @default.
- W3175487560 cites W1986780814 @default.
- W3175487560 cites W1990813852 @default.
- W3175487560 cites W1991233072 @default.
- W3175487560 cites W1991330646 @default.
- W3175487560 cites W1996053875 @default.
- W3175487560 cites W2009746412 @default.
- W3175487560 cites W2023817396 @default.
- W3175487560 cites W2033956919 @default.
- W3175487560 cites W2035840565 @default.
- W3175487560 cites W2045843097 @default.
- W3175487560 cites W2064043452 @default.
- W3175487560 cites W2067576392 @default.
- W3175487560 cites W2072186466 @default.
- W3175487560 cites W2076384957 @default.
- W3175487560 cites W2082373399 @default.
- W3175487560 cites W2090947027 @default.
- W3175487560 cites W2093261339 @default.
- W3175487560 cites W2096093282 @default.
- W3175487560 cites W2096992728 @default.
- W3175487560 cites W2097076431 @default.
- W3175487560 cites W2098681378 @default.
- W3175487560 cites W2101497046 @default.
- W3175487560 cites W2101779003 @default.
- W3175487560 cites W2102619694 @default.
- W3175487560 cites W2103441770 @default.
- W3175487560 cites W2107983230 @default.
- W3175487560 cites W2108234281 @default.
- W3175487560 cites W2114729422 @default.
- W3175487560 cites W2116206245 @default.
- W3175487560 cites W2119497560 @default.
- W3175487560 cites W2119738836 @default.
- W3175487560 cites W2120902911 @default.
- W3175487560 cites W2124558011 @default.
- W3175487560 cites W2129193499 @default.
- W3175487560 cites W2129267752 @default.
- W3175487560 cites W2131271579 @default.
- W3175487560 cites W2133986557 @default.
- W3175487560 cites W2134948698 @default.
- W3175487560 cites W2137686109 @default.
- W3175487560 cites W2137721714 @default.
- W3175487560 cites W2142447693 @default.
- W3175487560 cites W2144048071 @default.
- W3175487560 cites W2150342978 @default.
- W3175487560 cites W2150823021 @default.
- W3175487560 cites W2152106259 @default.
- W3175487560 cites W2152312795 @default.
- W3175487560 cites W2155767187 @default.
- W3175487560 cites W2158023121 @default.
- W3175487560 cites W2166154339 @default.
- W3175487560 cites W2206071891 @default.
- W3175487560 cites W2223993952 @default.
- W3175487560 cites W2340958225 @default.
- W3175487560 cites W2345791363 @default.
- W3175487560 cites W2405978957 @default.
- W3175487560 cites W2408820431 @default.
- W3175487560 cites W2417788788 @default.
- W3175487560 cites W2460507950 @default.
- W3175487560 cites W2527411440 @default.
- W3175487560 cites W2556833369 @default.
- W3175487560 cites W2600736805 @default.
- W3175487560 cites W2610656577 @default.
- W3175487560 cites W2623120792 @default.
- W3175487560 cites W2781863909 @default.
- W3175487560 cites W2783698286 @default.
- W3175487560 cites W2790921906 @default.
- W3175487560 cites W2791765621 @default.
- W3175487560 cites W2794550266 @default.
- W3175487560 cites W2912506384 @default.
- W3175487560 cites W2974490759 @default.
- W3175487560 cites W2986136624 @default.
- W3175487560 cites W3009004529 @default.
- W3175487560 cites W3027357144 @default.
- W3175487560 cites W4243227604 @default.
- W3175487560 cites W99305191 @default.
- W3175487560 doi "https://doi.org/10.1038/s41598-021-91737-8" @default.
- W3175487560 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8217490" @default.
- W3175487560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34155223" @default.
- W3175487560 hasPublicationYear "2021" @default.
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