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- W3175491246 abstract "OBJECTIVE Chronic hypoxia attenuates endothelium-dependent vasodilatation, more in fetal than adult arteries. Here we examine the hypothesis that these effects involve inhibition of PKG activity and reduced BK channel activity. METHODS Pregnant and Non-Pregnant ewes were held at sea level (normoxic) or at 3820m (hypoxic) for the final 110 days of gestation. Carotid arteries from non-pregnant adults and term fetal sheep were prepared for 5HT concentration-response determinations with ±8-pCPT-cGMP and ±iberiotoxin. Abundances of α/β isoforms of PKG-I were determined by Western blot. PKG activity was determined by enzyme assay. RESULTS PKG activation depressed 5HT-induced contractility in normoxic but not hypoxic arteries. Hypoxia did not alter PKG abundance or specific activity but reduced iberiotoxin's ability to block PKG's effect on 5HT-induced contractions, more in fetal than adult arteries. CONCLUSION Activation of BK channels accounts for a significant portion of PKG-induced vasorelaxation in ovine carotid arteries. Chronic hypoxia attenuates the ability of PKG to activate BK channels without effects on PKG activity or abundance. Supported by PHS Grants P01-HD31226 and R01-HL64867." @default.
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- W3175491246 date "2012-04-01" @default.
- W3175491246 modified "2023-10-17" @default.
- W3175491246 title "Hypoxia attenuates the ability of cyclic guanine‐dependent protein kinase (PKG) to increase BK channel activity" @default.
- W3175491246 doi "https://doi.org/10.1096/fasebj.26.1_supplement.870.30" @default.
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