FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3175492049> ?p ?o ?g. }

• W3175492049 endingPage "319" @default.
• W3175492049 startingPage "307" @default.
• W3175492049 abstract "Dysregulation of the Wnt pathway causes various diseases including cancer, Parkinson's disease, Alzheimer's disease, schizophrenia, osteoporosis, obesity and chronic kidney diseases. The modulation of dysregulated Wnt pathway is absolutely necessary. In the present study, we evaluated the anti-inflammatory effect and the mechanism of action of Wnt-C59, a Wnt signaling inhibitor, in lipopolysaccharide (LPS)-stimulated epithelial cells and macrophage cells. Wnt-C59 showed a dose-dependent anti-inflammatory effect by suppressing the expression of proinflammatory cytokines including IL6, CCL2, IL1A, IL1B, and TNF in LPS-stimulated cells. The dysregulation of the Wnt/β-catenin pathway in LPS stimulated cells was suppressed by Wnt- C59 treatment. The level of β-catenin, the executor protein of Wnt/β-catenin pathway, was elevated by LPS and suppressed by Wnt-C59. Overexpression of β-catenin rescued the suppressive effect of Wnt-C59 on proinflammatory cytokine expression and nuclear factor-kappa B (NF-κB) activity. We found that the interaction between β-catenin and NF-κB, measured by co-immunoprecipitation assay, was elevated by LPS and suppressed by Wnt-C59 treatment. Both NF-κB activity for its target DNA binding and the reporter activity of NF-κB-responsive promoter showed identical patterns with the interaction between β-catenin and NF-κB. Altogether, our findings suggest that the anti-inflammatory effect of Wnt-C59 is mediated by the reduction of the cellular level of β-catenin and the interaction between β-catenin and NF-κB, which results in the suppressions of the NF-κB activity and proinflammatory cytokine expression." @default.
• W3175492049 created "2021-07-05" @default.
• W3175492049 creator A5031717526 @default.
• W3175492049 creator A5039412044 @default.
• W3175492049 creator A5069580134 @default.
• W3175492049 creator A5088787476 @default.
• W3175492049 date "2021-07-01" @default.
• W3175492049 modified "2023-10-12" @default.
• W3175492049 title "Wnt-C59 inhibits proinflammatory cytokine expression by reducing the interaction between β-catenin and NF-κB in LPS-stimulated epithelial and macrophage cells" @default.
• W3175492049 cites W1586218645 @default.
• W3175492049 cites W1771639668 @default.
• W3175492049 cites W1966180339 @default.
• W3175492049 cites W1983788003 @default.
• W3175492049 cites W2013429896 @default.
• W3175492049 cites W2020018765 @default.
• W3175492049 cites W2032419594 @default.
• W3175492049 cites W2038249157 @default.
• W3175492049 cites W2049081574 @default.
• W3175492049 cites W2107277218 @default.
• W3175492049 cites W2116959561 @default.
• W3175492049 cites W2129854864 @default.
• W3175492049 cites W2131923232 @default.
• W3175492049 cites W2138924822 @default.
• W3175492049 cites W2144796426 @default.
• W3175492049 cites W2160649260 @default.
• W3175492049 cites W2164702681 @default.
• W3175492049 cites W2166251636 @default.
• W3175492049 cites W2214552500 @default.
• W3175492049 cites W2308877979 @default.
• W3175492049 cites W2462845880 @default.
• W3175492049 cites W2520632143 @default.
• W3175492049 cites W2522422641 @default.
• W3175492049 cites W2538205969 @default.
• W3175492049 cites W2582790611 @default.
• W3175492049 cites W2617377603 @default.
• W3175492049 cites W2776878927 @default.
• W3175492049 cites W2790195606 @default.
• W3175492049 cites W2800233418 @default.
• W3175492049 cites W2805720950 @default.
• W3175492049 cites W2891968161 @default.
• W3175492049 cites W3035222954 @default.
• W3175492049 cites W3038025810 @default.
• W3175492049 cites W2753287992 @default.
• W3175492049 doi "https://doi.org/10.4196/kjpp.2021.25.4.307" @default.
• W3175492049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8255128" @default.
• W3175492049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34193644" @default.
• W3175492049 hasPublicationYear "2021" @default.
• W3175492049 type Work @default.
• W3175492049 sameAs 3175492049 @default.
• W3175492049 citedByCount "4" @default.
• W3175492049 countsByYear W31754920492022 @default.
• W3175492049 countsByYear W31754920492023 @default.
• W3175492049 crossrefType "journal-article" @default.
• W3175492049 hasAuthorship W3175492049A5031717526 @default.
• W3175492049 hasAuthorship W3175492049A5039412044 @default.
• W3175492049 hasAuthorship W3175492049A5069580134 @default.
• W3175492049 hasAuthorship W3175492049A5088787476 @default.
• W3175492049 hasBestOaLocation W31754920491 @default.
• W3175492049 hasConcept C137620995 @default.
• W3175492049 hasConcept C164027704 @default.
• W3175492049 hasConcept C202751555 @default.
• W3175492049 hasConcept C203014093 @default.
• W3175492049 hasConcept C2776914184 @default.
• W3175492049 hasConcept C2777730290 @default.
• W3175492049 hasConcept C2778690821 @default.
• W3175492049 hasConcept C2779244956 @default.
• W3175492049 hasConcept C30145163 @default.
• W3175492049 hasConcept C502942594 @default.
• W3175492049 hasConcept C55493867 @default.
• W3175492049 hasConcept C62478195 @default.
• W3175492049 hasConcept C71924100 @default.
• W3175492049 hasConcept C86803240 @default.
• W3175492049 hasConcept C95444343 @default.
• W3175492049 hasConceptScore W3175492049C137620995 @default.
• W3175492049 hasConceptScore W3175492049C164027704 @default.
• W3175492049 hasConceptScore W3175492049C202751555 @default.
• W3175492049 hasConceptScore W3175492049C203014093 @default.
• W3175492049 hasConceptScore W3175492049C2776914184 @default.
• W3175492049 hasConceptScore W3175492049C2777730290 @default.
• W3175492049 hasConceptScore W3175492049C2778690821 @default.
• W3175492049 hasConceptScore W3175492049C2779244956 @default.
• W3175492049 hasConceptScore W3175492049C30145163 @default.
• W3175492049 hasConceptScore W3175492049C502942594 @default.
• W3175492049 hasConceptScore W3175492049C55493867 @default.
• W3175492049 hasConceptScore W3175492049C62478195 @default.
• W3175492049 hasConceptScore W3175492049C71924100 @default.
• W3175492049 hasConceptScore W3175492049C86803240 @default.
• W3175492049 hasConceptScore W3175492049C95444343 @default.
• W3175492049 hasFunder F4320321202 @default.
• W3175492049 hasFunder F4320322120 @default.
• W3175492049 hasIssue "4" @default.
• W3175492049 hasLocation W31754920491 @default.
• W3175492049 hasOpenAccess W3175492049 @default.
• W3175492049 hasPrimaryLocation W31754920491 @default.
• W3175492049 hasRelatedWork W1902535750 @default.
• W3175492049 hasRelatedWork W2010867414 @default.
• W3175492049 hasRelatedWork W2047578621 @default.
• W3175492049 hasRelatedWork W2135919238 @default.

• next