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- W3175500985 abstract "Abstract Relaxin/insulin-like-family peptide receptor-4 (RXFP4), the cognate receptor for insulin-like peptide 5 (INSL5), has previously been implicated in feeding behaviour. To explore Rxfp4 expression and physiology, we generated Rxfp4 -Cre mice. Whole body chemogenetic activation (Dq) or inhibition (Di) of Rxfp4 -expressing cells using designer receptors exclusively activated by designer drugs (DREADDs) altered food intake and preference. Potentially underlying this effect, Rxfp4 -expressing neurons were identified in nodose and dorsal root ganglia and the central nervous system, including the ventromedial hypothalamus (VMH). Single-cell RNA-sequencing defined a cluster of VMH Rxfp4 -labelled cells expressing Esr1, Tac1 and Oxtr . VMH-restricted activation of Rxfp4 -expressing (RXFP4 VMH ) cells using AAV-Dq recapitulated the whole body Dq feeding phenotype. Viral tracing demonstrated RXFP4 VMH neural projections to the bed nucleus of the stria terminalis, paraventricular hypothalamus, paraventricular thalamus, central nucleus of the amygdala and parabrachial nucleus. These findings identify hypothalamic RXFP4 signalling as a key regulator of food intake and preference." @default.
- W3175500985 created "2021-07-05" @default.
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- W3175500985 date "2021-06-28" @default.
- W3175500985 modified "2023-10-15" @default.
- W3175500985 title "Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice" @default.
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- W3175500985 doi "https://doi.org/10.1101/2021.06.26.450020" @default.
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