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- W3175503996 abstract "Complications from the upper Gl tract associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) is a serious social and medical problem. The number of people who need NSAIDs and low doses of aspirin is steadily increasing. Most of them are represented by elderly people who have a serious comorbid pathology, significantly increasing the risk of developing drug complications. The incidence of NSAID-gastropathy remains high even after the introduction of selective inhibitors of cyclooxygenase-2 (COX) and obvious success in the treatment of H.pylori-associated peptic ulcers. Gastrointestinal bleeding and perforation, which occur when taking NSAIDs, are accompanied by high mortality and require serious costs for treatment. This determines the need for adequate prevention of this pathology. The main methods for the prevention of NSAIDs are the management of risk factors, the use of safer drugs of this group and the appointment of antiulcer drugs that reduce the risk of erosive ulcer changes and bleeding. A new drug for the prevention of gastrointestinal complications against the background of NSAIDs and antithrombotic agents is the gastroenteroprotector rebamipide. The advantage of this drug is associated with the ability to prevent not only the development of erosions and ulcers of the upper gastrointestinal tract, but also of the small and large intestine." @default.
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- W3175503996 date "2017-12-27" @default.
- W3175503996 modified "2023-09-25" @default.
- W3175503996 title "Проблема НПВП-гастропатии: современные представления" @default.
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