FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3175514351> ?p ?o ?g. }

• W3175514351 endingPage "120976" @default.
• W3175514351 startingPage "120976" @default.
• W3175514351 abstract "Differentiated kidney organoids from induced pluripotent stem cells hold promise as a treatment for patients with kidney diseases. Before these organoids can be translated to the clinic, shortcomings regarding their cellular and extracellular compositions, and their developmental plateau need to be overcome. We performed a proteomic analysis on kidney organoids cultured for a prolonged culture time and we found a specific change in the extracellular matrix composition with increased expression of types 1a1, 2 and 6a1 collagen. Such an excessive accumulation of specific collagen types is a hallmark of renal fibrosis that causes a life-threatening pathological condition by compromising key functions of the human kidney. Here we hypothesized the need for a three-dimensional environment to grow the kidney organoids, which could better mimic the in vivo surroundings of the developing kidney than standard culture on an air-liquid interface. Encapsulating organoids for four days in a soft, thiol-ene cross-linked alginate hydrogel resulted in decreased type 1a1 collagen expression. Furthermore, the encapsulation did not result in any changes of organoid structural morphology. Using a biomaterial to modulate collagen expression allows for a prolonged kidney organoid culture in vitro and a reduction of abnormal type 1a1 collagen expression bringing kidney organoids closer to clinical application." @default.
• W3175514351 created "2021-07-05" @default.
• W3175514351 creator A5003134066 @default.
• W3175514351 creator A5003173270 @default.
• W3175514351 creator A5020130906 @default.
• W3175514351 creator A5024006929 @default.
• W3175514351 creator A5038024548 @default.
• W3175514351 creator A5041224469 @default.
• W3175514351 creator A5044462633 @default.
• W3175514351 creator A5056551110 @default.
• W3175514351 creator A5058078757 @default.
• W3175514351 creator A5091735449 @default.
• W3175514351 date "2021-08-01" @default.
• W3175514351 modified "2023-10-12" @default.
• W3175514351 title "Thiol-ene cross-linked alginate hydrogel encapsulation modulates the extracellular matrix of kidney organoids by reducing abnormal type 1a1 collagen deposition" @default.
• W3175514351 cites W1684625763 @default.
• W3175514351 cites W1802574002 @default.
• W3175514351 cites W1862989971 @default.
• W3175514351 cites W1983097616 @default.
• W3175514351 cites W1985914247 @default.
• W3175514351 cites W1996187477 @default.
• W3175514351 cites W2020992600 @default.
• W3175514351 cites W2097103130 @default.
• W3175514351 cites W2103883318 @default.
• W3175514351 cites W2108579114 @default.
• W3175514351 cites W2116055752 @default.
• W3175514351 cites W2116228354 @default.
• W3175514351 cites W2154223976 @default.
• W3175514351 cites W2158683031 @default.
• W3175514351 cites W2162003385 @default.
• W3175514351 cites W2176166968 @default.
• W3175514351 cites W2192723508 @default.
• W3175514351 cites W2282335838 @default.
• W3175514351 cites W2403380354 @default.
• W3175514351 cites W2463195069 @default.
• W3175514351 cites W2470481127 @default.
• W3175514351 cites W2492962850 @default.
• W3175514351 cites W2510238988 @default.
• W3175514351 cites W2510564348 @default.
• W3175514351 cites W2513623015 @default.
• W3175514351 cites W2519646646 @default.
• W3175514351 cites W2531835077 @default.
• W3175514351 cites W2759855214 @default.
• W3175514351 cites W2763153129 @default.
• W3175514351 cites W2766832099 @default.
• W3175514351 cites W2767871975 @default.
• W3175514351 cites W2791909710 @default.
• W3175514351 cites W2802405809 @default.
• W3175514351 cites W2803432473 @default.
• W3175514351 cites W2804037024 @default.
• W3175514351 cites W2808008314 @default.
• W3175514351 cites W2810959581 @default.
• W3175514351 cites W2890099733 @default.
• W3175514351 cites W2890540126 @default.
• W3175514351 cites W2900036104 @default.
• W3175514351 cites W2901335962 @default.
• W3175514351 cites W2912021608 @default.
• W3175514351 cites W2919899673 @default.
• W3175514351 cites W2945382930 @default.
• W3175514351 cites W2949559557 @default.
• W3175514351 cites W2957305095 @default.
• W3175514351 cites W2967025071 @default.
• W3175514351 cites W3021936948 @default.
• W3175514351 cites W4211124701 @default.
• W3175514351 cites W4211210745 @default.
• W3175514351 doi "https://doi.org/10.1016/j.biomaterials.2021.120976" @default.
• W3175514351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34198162" @default.
• W3175514351 hasPublicationYear "2021" @default.
• W3175514351 type Work @default.
• W3175514351 sameAs 3175514351 @default.
• W3175514351 citedByCount "28" @default.
• W3175514351 countsByYear W31755143512021 @default.
• W3175514351 countsByYear W31755143512022 @default.
• W3175514351 countsByYear W31755143512023 @default.
• W3175514351 crossrefType "journal-article" @default.
• W3175514351 hasAuthorship W3175514351A5003134066 @default.
• W3175514351 hasAuthorship W3175514351A5003173270 @default.
• W3175514351 hasAuthorship W3175514351A5020130906 @default.
• W3175514351 hasAuthorship W3175514351A5024006929 @default.
• W3175514351 hasAuthorship W3175514351A5038024548 @default.
• W3175514351 hasAuthorship W3175514351A5041224469 @default.
• W3175514351 hasAuthorship W3175514351A5044462633 @default.
• W3175514351 hasAuthorship W3175514351A5056551110 @default.
• W3175514351 hasAuthorship W3175514351A5058078757 @default.
• W3175514351 hasAuthorship W3175514351A5091735449 @default.
• W3175514351 hasBestOaLocation W31755143511 @default.
• W3175514351 hasConcept C104317684 @default.
• W3175514351 hasConcept C107459253 @default.
• W3175514351 hasConcept C134018914 @default.
• W3175514351 hasConcept C145103041 @default.
• W3175514351 hasConcept C185592680 @default.
• W3175514351 hasConcept C189165786 @default.
• W3175514351 hasConcept C2780091579 @default.
• W3175514351 hasConcept C28406088 @default.
• W3175514351 hasConcept C31695470 @default.
• W3175514351 hasConcept C55493867 @default.
• W3175514351 hasConcept C86803240 @default.
• W3175514351 hasConcept C95444343 @default.

• next