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• W3175541992 abstract "The frequency of azoxymethane/dextran sulfate sodium (AOM/DSS)-induced carcinogenesis in male mice is higher than that in female mice. Previous studies have reported that 17β-estradiol inhibits tumorigenesis in males by modulating nuclear factor-erythroid 2-related factor 2 (Nrf2). This study aimed to investigate the changes in mouse gut microbiome composition based on sex, AOM/DSS-induced colorectal cancer (CRC), and Nrf2 genotype. The gut microbiome composition was determined by 16S rRNA gene sequencing fecal samples obtained at week 16 post-AOM administration. In terms of sex differences, our results showed that the wild-type (WT) male control mice had higher alpha diversity (i.e. Chao1, Shannon, and Simpson) than the WT female control mice. The linear discriminant analysis effect size (LEfSe) results revealed that the abundances of Akkermansia muciniphila and Lactobacillus murinus were higher in WT male control mice than in WT female controls. In terms of colon tumorigenesis, the alpha diversity of the male CRC group was lower than that of the male controls in both WT and Nrf2 KO, but did not show such changes in females. Furthermore, the abundance of A. muciniphila was higher in male CRC groups than in male controls in both WT and Nrf2 KO. The abundance of Bacteroides vulgatus was higher in WT CRC groups than in WT controls in both males and females. However, the abundance of L. murinus was lower in WT female CRC and Nrf2 KO male CRC groups than in its controls. The abundance of A. muciniphila was not altered by Nrf2 KO. In contrast, the abundances of L. murinus and B. vulgatus were changed differently by Nrf2 KO depending on sex and CRC. Interestingly, L. murinus showed negative correlation with tumor numbers in the whole colon. In addition, B. vulgatus showed positive correlation with inflammatory markers (i.e. myeloperoxidase and IL-1β levels), tumor numbers, and high-grade adenoma, especially, developed mucosal and submucosal invasive adenocarcinoma at the distal part of the colon. In conclusion, Nrf2 differentially alters the gut microbiota composition depending on sex and CRC induction." @default.
• W3175541992 created "2021-07-05" @default.
• W3175541992 creator A5015129955 @default.
• W3175541992 creator A5017168777 @default.
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• W3175541992 creator A5044276949 @default.
• W3175541992 creator A5047996963 @default.
• W3175541992 creator A5073217800 @default.
• W3175541992 date "2021-06-23" @default.
• W3175541992 modified "2023-09-27" @default.
• W3175541992 title "Changes in Microbial Community Composition Related to Sex and Colon Cancer by Nrf2 Knockout" @default.
• W3175541992 cites W1192393331 @default.
• W3175541992 cites W1597959509 @default.
• W3175541992 cites W1603190237 @default.
• W3175541992 cites W190681677 @default.
• W3175541992 cites W1918288286 @default.
• W3175541992 cites W1967577899 @default.
• W3175541992 cites W1971084951 @default.
• W3175541992 cites W1980949357 @default.
• W3175541992 cites W1989401467 @default.
• W3175541992 cites W1990805260 @default.
• W3175541992 cites W1995875735 @default.
• W3175541992 cites W2003525072 @default.
• W3175541992 cites W2004549986 @default.
• W3175541992 cites W2024180465 @default.
• W3175541992 cites W2025039508 @default.
• W3175541992 cites W2027085316 @default.
• W3175541992 cites W2033743084 @default.
• W3175541992 cites W2036720571 @default.
• W3175541992 cites W2038984140 @default.
• W3175541992 cites W2047059509 @default.
• W3175541992 cites W2059378857 @default.
• W3175541992 cites W2063170504 @default.
• W3175541992 cites W2067611825 @default.
• W3175541992 cites W2071897958 @default.
• W3175541992 cites W2084070275 @default.
• W3175541992 cites W2085991415 @default.
• W3175541992 cites W2087189381 @default.
• W3175541992 cites W2097875133 @default.
• W3175541992 cites W2102759586 @default.
• W3175541992 cites W2106742466 @default.
• W3175541992 cites W2107974372 @default.
• W3175541992 cites W2124351063 @default.
• W3175541992 cites W2131271579 @default.
• W3175541992 cites W2132548846 @default.
• W3175541992 cites W2133856765 @default.
• W3175541992 cites W2136879569 @default.
• W3175541992 cites W2137096265 @default.
• W3175541992 cites W2138122982 @default.
• W3175541992 cites W2142536690 @default.
• W3175541992 cites W2149573313 @default.
• W3175541992 cites W2150155658 @default.
• W3175541992 cites W2155924614 @default.
• W3175541992 cites W2161548174 @default.
• W3175541992 cites W2164414963 @default.
• W3175541992 cites W2167062509 @default.
• W3175541992 cites W2170747616 @default.
• W3175541992 cites W2191485736 @default.
• W3175541992 cites W2232428085 @default.
• W3175541992 cites W2394804118 @default.
• W3175541992 cites W2395064609 @default.
• W3175541992 cites W2404939443 @default.
• W3175541992 cites W2417535489 @default.
• W3175541992 cites W2473762402 @default.
• W3175541992 cites W2484808885 @default.
• W3175541992 cites W2517943671 @default.
• W3175541992 cites W2563805385 @default.
• W3175541992 cites W2611418622 @default.
• W3175541992 cites W2640475594 @default.
• W3175541992 cites W2655728305 @default.
• W3175541992 cites W2738512963 @default.
• W3175541992 cites W2750838281 @default.
• W3175541992 cites W2756391458 @default.
• W3175541992 cites W2757963838 @default.
• W3175541992 cites W2776878739 @default.
• W3175541992 cites W2804697849 @default.
• W3175541992 cites W2808824631 @default.
• W3175541992 cites W2887239928 @default.
• W3175541992 cites W2889926944 @default.
• W3175541992 cites W2899474804 @default.
• W3175541992 cites W2900494132 @default.
• W3175541992 cites W2909798892 @default.
• W3175541992 cites W2910159017 @default.
• W3175541992 cites W2922893172 @default.
• W3175541992 cites W2940429062 @default.
• W3175541992 cites W2941578712 @default.
• W3175541992 cites W2942110779 @default.
• W3175541992 cites W2943821839 @default.
• W3175541992 cites W2964200492 @default.
• W3175541992 cites W2979380114 @default.
• W3175541992 cites W2979506777 @default.
• W3175541992 cites W2983737327 @default.
• W3175541992 cites W2986476597 @default.
• W3175541992 cites W3006073359 @default.
• W3175541992 cites W3019850324 @default.
• W3175541992 cites W3045466794 @default.
• W3175541992 cites W3080373088 @default.
• W3175541992 cites W3090009360 @default.
• W3175541992 cites W3092687283 @default.

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