FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3175551773> ?p ?o ?g. }

• W3175551773 abstract "Abstract Background The presence of hypoxia is a poor prognostic factor in prostate cancer and the hypoxic tumor microenvironment promotes radioresistance. There is potential for drug radiotherapy combinations to improve the therapeutic ratio. We aimed to investigate whether hypoxia-associated genes could be used to identify FDA approved drugs for repurposing for the treatment of hypoxic prostate cancer. Methods Hypoxia associated genes were identified and used in the connectivity mapping software QUADrATIC to identify FDA approved drugs as candidates for repurposing. Drugs identified were tested in vitro in prostate cancer cell lines (DU145, PC3, LNCAP). Cytotoxicity was investigated using the sulforhodamine B assay and radiosensitization using a clonogenic assay in normoxia and hypoxia. Results Menadione and gemcitabine had similar cytotoxicity in normoxia and hypoxia in all three cell lines. In DU145 cells, the radiation sensitizer enhancement ratio (SER) of menadione was 1.02 in normoxia and 1.15 in hypoxia. The SER of gemcitabine was 1.27 in normoxia and 1.09 in hypoxia. No radiosensitization was seen in PC3 cells. Conclusion Connectivity mapping can identify FDA approved drugs for potential repurposing that are linked to a radiobiologically relevant phenotype. Gemcitabine and menadione could be further investigated as potential radiosensitizers in prostate cancer." @default.
• W3175551773 created "2021-07-05" @default.
• W3175551773 creator A5008176647 @default.
• W3175551773 creator A5020744487 @default.
• W3175551773 creator A5027461503 @default.
• W3175551773 creator A5027750074 @default.
• W3175551773 creator A5031947326 @default.
• W3175551773 creator A5039482198 @default.
• W3175551773 creator A5041859071 @default.
• W3175551773 creator A5063482303 @default.
• W3175551773 creator A5066893635 @default.
• W3175551773 creator A5067936202 @default.
• W3175551773 creator A5079894409 @default.
• W3175551773 date "2021-07-01" @default.
• W3175551773 modified "2023-10-02" @default.
• W3175551773 title "Repurposing FDA approved drugs as radiosensitizers for treating hypoxic prostate cancer" @default.
• W3175551773 cites W1824413195 @default.
• W3175551773 cites W1893283179 @default.
• W3175551773 cites W1900078466 @default.
• W3175551773 cites W1975330789 @default.
• W3175551773 cites W1981370484 @default.
• W3175551773 cites W1984736888 @default.
• W3175551773 cites W1986947429 @default.
• W3175551773 cites W1991264254 @default.
• W3175551773 cites W1992548667 @default.
• W3175551773 cites W2003667308 @default.
• W3175551773 cites W2003813442 @default.
• W3175551773 cites W2005853803 @default.
• W3175551773 cites W2017119076 @default.
• W3175551773 cites W2018722597 @default.
• W3175551773 cites W2026576427 @default.
• W3175551773 cites W2027542963 @default.
• W3175551773 cites W2029980980 @default.
• W3175551773 cites W2037678633 @default.
• W3175551773 cites W2039212334 @default.
• W3175551773 cites W2057617621 @default.
• W3175551773 cites W2068927098 @default.
• W3175551773 cites W2069978426 @default.
• W3175551773 cites W2076255654 @default.
• W3175551773 cites W2105537697 @default.
• W3175551773 cites W2107633226 @default.
• W3175551773 cites W2108696043 @default.
• W3175551773 cites W2123500593 @default.
• W3175551773 cites W2125675894 @default.
• W3175551773 cites W2130834017 @default.
• W3175551773 cites W2131681506 @default.
• W3175551773 cites W2132834292 @default.
• W3175551773 cites W2132970479 @default.
• W3175551773 cites W2137330819 @default.
• W3175551773 cites W2138253517 @default.
• W3175551773 cites W2142301211 @default.
• W3175551773 cites W2143274699 @default.
• W3175551773 cites W2145616568 @default.
• W3175551773 cites W2157502781 @default.
• W3175551773 cites W2157945371 @default.
• W3175551773 cites W2163763232 @default.
• W3175551773 cites W2345869233 @default.
• W3175551773 cites W2415000849 @default.
• W3175551773 cites W2465705692 @default.
• W3175551773 cites W2499786133 @default.
• W3175551773 cites W2514972769 @default.
• W3175551773 cites W2537623931 @default.
• W3175551773 cites W2560639583 @default.
• W3175551773 cites W2595613062 @default.
• W3175551773 cites W2598265731 @default.
• W3175551773 cites W2605993275 @default.
• W3175551773 cites W2762477263 @default.
• W3175551773 cites W2799942610 @default.
• W3175551773 cites W2901016056 @default.
• W3175551773 cites W2937483840 @default.
• W3175551773 cites W3023465048 @default.
• W3175551773 cites W3102695902 @default.
• W3175551773 doi "https://doi.org/10.1186/s12894-021-00856-x" @default.
• W3175551773 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8247203" @default.
• W3175551773 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34210300" @default.
• W3175551773 hasPublicationYear "2021" @default.
• W3175551773 type Work @default.
• W3175551773 sameAs 3175551773 @default.
• W3175551773 citedByCount "5" @default.
• W3175551773 countsByYear W31755517732021 @default.
• W3175551773 countsByYear W31755517732022 @default.
• W3175551773 countsByYear W31755517732023 @default.
• W3175551773 crossrefType "journal-article" @default.
• W3175551773 hasAuthorship W3175551773A5008176647 @default.
• W3175551773 hasAuthorship W3175551773A5020744487 @default.
• W3175551773 hasAuthorship W3175551773A5027461503 @default.
• W3175551773 hasAuthorship W3175551773A5027750074 @default.
• W3175551773 hasAuthorship W3175551773A5031947326 @default.
• W3175551773 hasAuthorship W3175551773A5039482198 @default.
• W3175551773 hasAuthorship W3175551773A5041859071 @default.
• W3175551773 hasAuthorship W3175551773A5063482303 @default.
• W3175551773 hasAuthorship W3175551773A5066893635 @default.
• W3175551773 hasAuthorship W3175551773A5067936202 @default.
• W3175551773 hasAuthorship W3175551773A5079894409 @default.
• W3175551773 hasBestOaLocation W31755517731 @default.
• W3175551773 hasConcept C121608353 @default.
• W3175551773 hasConcept C126322002 @default.
• W3175551773 hasConcept C143998085 @default.
• W3175551773 hasConcept C178790620 @default.
• W3175551773 hasConcept C185592680 @default.

• next