FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3175580947> ?p ?o ?g. }

• W3175580947 endingPage "2293" @default.
• W3175580947 startingPage "2285" @default.
• W3175580947 abstract "The SmeVWX efflux pump of Stenotrophomonas maltophilia contributes to menadione (MD) tolerance and resistance to chloramphenicol, quinolones and tetracycline. The components of the SmeVWX efflux pump are encoded by a five-gene operon, smeU1VWU2X. We have previously demonstrated that the smeU1VWU2X operon is intrinsically unexpressed and inducibly expressed by MD via a SoxR- and SmeRv-involved regulatory circuit in S. maltophilia KJ. We also inferred that there should be other regulator(s) involved in MD-mediated smeU1VWU2X expression in addition to SoxR and SmeRv.To identify novel regulator(s) involved in the regulation of MD-mediated smeU1VWU2X expression and elucidate the regulatory circuit.A possible regulator candidate involved in the regulation of MD-mediated smeU1VWU2X expression was identified by a homologue search using the helix-turn-helix domain of SmeRv as a query. Gene expression was assessed using the promoter-xylE transcriptional fusion assay and quantitative RT-PCR. The impact of the regulator on SmeVWX pump-mediated functions was investigated via mutant construction and functional tests (antibiotic susceptibility and MD tolerance).AzoR (Smlt3089), a LysR-type transcriptional regulator, was investigated. In unstressed logarithmically grown cells, AzoR was abundantly expressed and functioned as a repressor, inhibiting the expression of the smeU1VWU2X operon. MD challenge attenuated azoR expression, thus derepressing the expression of the smeU1VWU2X operon in S. maltophilia KJ. AzoR down-regulation-mediated smeU1VWU2X expression was observed in quinolone-resistant and SmeVWX-overexpressing S. maltophilia clinical isolates.AzoR negatively regulates the expression of the smeU1VWU2X operon and SmeVWX pump-mediated antibiotic resistance in S. maltophilia." @default.
• W3175580947 created "2021-07-05" @default.
• W3175580947 creator A5019762882 @default.
• W3175580947 creator A5023753100 @default.
• W3175580947 creator A5064144151 @default.
• W3175580947 creator A5083033050 @default.
• W3175580947 creator A5088574782 @default.
• W3175580947 date "2021-06-21" @default.
• W3175580947 modified "2023-09-24" @default.
• W3175580947 title "Role of AzoR, a LysR-type transcriptional regulator, in SmeVWX pump-mediated antibiotic resistance in <i>Stenotrophomonas maltophilia</i>" @default.
• W3175580947 cites W1924338650 @default.
• W3175580947 cites W1977445635 @default.
• W3175580947 cites W1997736352 @default.
• W3175580947 cites W1999979510 @default.
• W3175580947 cites W2039427303 @default.
• W3175580947 cites W2061404600 @default.
• W3175580947 cites W2065652119 @default.
• W3175580947 cites W2069480047 @default.
• W3175580947 cites W2098992986 @default.
• W3175580947 cites W2100972153 @default.
• W3175580947 cites W2107277218 @default.
• W3175580947 cites W2127490249 @default.
• W3175580947 cites W2145958601 @default.
• W3175580947 cites W2149103203 @default.
• W3175580947 cites W2150193089 @default.
• W3175580947 cites W2166024337 @default.
• W3175580947 cites W2167796111 @default.
• W3175580947 cites W2567003262 @default.
• W3175580947 cites W2587918806 @default.
• W3175580947 cites W2767735528 @default.
• W3175580947 cites W2770890865 @default.
• W3175580947 cites W2771542543 @default.
• W3175580947 cites W2805006949 @default.
• W3175580947 cites W2940137195 @default.
• W3175580947 cites W2964042071 @default.
• W3175580947 doi "https://doi.org/10.1093/jac/dkab203" @default.
• W3175580947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34151959" @default.
• W3175580947 hasPublicationYear "2021" @default.
• W3175580947 type Work @default.
• W3175580947 sameAs 3175580947 @default.
• W3175580947 citedByCount "2" @default.
• W3175580947 countsByYear W31755809472023 @default.
• W3175580947 crossrefType "journal-article" @default.
• W3175580947 hasAuthorship W3175580947A5019762882 @default.
• W3175580947 hasAuthorship W3175580947A5023753100 @default.
• W3175580947 hasAuthorship W3175580947A5064144151 @default.
• W3175580947 hasAuthorship W3175580947A5083033050 @default.
• W3175580947 hasAuthorship W3175580947A5088574782 @default.
• W3175580947 hasConcept C104317684 @default.
• W3175580947 hasConcept C143065580 @default.
• W3175580947 hasConcept C150194340 @default.
• W3175580947 hasConcept C153911025 @default.
• W3175580947 hasConcept C158448853 @default.
• W3175580947 hasConcept C165864922 @default.
• W3175580947 hasConcept C170344550 @default.
• W3175580947 hasConcept C200082930 @default.
• W3175580947 hasConcept C203075996 @default.
• W3175580947 hasConcept C27153228 @default.
• W3175580947 hasConcept C2776352461 @default.
• W3175580947 hasConcept C2777274385 @default.
• W3175580947 hasConcept C2777637488 @default.
• W3175580947 hasConcept C33498276 @default.
• W3175580947 hasConcept C523546767 @default.
• W3175580947 hasConcept C54355233 @default.
• W3175580947 hasConcept C6929976 @default.
• W3175580947 hasConcept C86803240 @default.
• W3175580947 hasConcept C89423630 @default.
• W3175580947 hasConceptScore W3175580947C104317684 @default.
• W3175580947 hasConceptScore W3175580947C143065580 @default.
• W3175580947 hasConceptScore W3175580947C150194340 @default.
• W3175580947 hasConceptScore W3175580947C153911025 @default.
• W3175580947 hasConceptScore W3175580947C158448853 @default.
• W3175580947 hasConceptScore W3175580947C165864922 @default.
• W3175580947 hasConceptScore W3175580947C170344550 @default.
• W3175580947 hasConceptScore W3175580947C200082930 @default.
• W3175580947 hasConceptScore W3175580947C203075996 @default.
• W3175580947 hasConceptScore W3175580947C27153228 @default.
• W3175580947 hasConceptScore W3175580947C2776352461 @default.
• W3175580947 hasConceptScore W3175580947C2777274385 @default.
• W3175580947 hasConceptScore W3175580947C2777637488 @default.
• W3175580947 hasConceptScore W3175580947C33498276 @default.
• W3175580947 hasConceptScore W3175580947C523546767 @default.
• W3175580947 hasConceptScore W3175580947C54355233 @default.
• W3175580947 hasConceptScore W3175580947C6929976 @default.
• W3175580947 hasConceptScore W3175580947C86803240 @default.
• W3175580947 hasConceptScore W3175580947C89423630 @default.
• W3175580947 hasFunder F4320309618 @default.
• W3175580947 hasFunder F4320322795 @default.
• W3175580947 hasFunder F4320323524 @default.
• W3175580947 hasIssue "9" @default.
• W3175580947 hasLocation W31755809471 @default.
• W3175580947 hasLocation W31755809472 @default.
• W3175580947 hasOpenAccess W3175580947 @default.
• W3175580947 hasPrimaryLocation W31755809471 @default.
• W3175580947 hasRelatedWork W2023905906 @default.
• W3175580947 hasRelatedWork W2052634897 @default.
• W3175580947 hasRelatedWork W2092209084 @default.
• W3175580947 hasRelatedWork W2119509827 @default.

• next