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• W3175602039 endingPage "120854" @default.
• W3175602039 startingPage "120854" @default.
• W3175602039 abstract "3D printed pharmaceuticals offers the potential to manufacture personalized medicines for patients. Such technology is of particular benefit to pediatric populations from the offer of increased patient compliance and dose flexibility. With a bench-to-patient approach, this study established and optimized the critical parameters of the semi-solid micro-extrusion 3D printing process to guarantee the quality attributes of the final dosage form. Pediatrics orodispersible printlets of hydrochlorothiazide were manufactured through the modification of printing parameters, as well as printing surfaces materials. The printlets were characterized and the dimensions were measured using a digital caliper and computer vision algorithm. This study identified that the printing surface material and the first printing layer are critical parameters for high-resolution printlets. Following the optimization of 3D printing parameters, high quality orodispersible printlets loaded with hydrochlorothiazide – specifically tailored for pediatric patient’s dosage forms – were obtained (4.62 mm × 1.90 mm). Mass and content uniformity assays demonstrated that the printlets satisfied the requirements for orodispersible printlets set by the European Pharmacopoeia. As such, in order to transition from laboratory research towards the treatment of patients, distinguishing accurate 3D printing parameters is necessary for the manufacture of medicines with key quality attributes that follow Pharmacopoeia requirements." @default.
• W3175602039 created "2021-07-05" @default.
• W3175602039 creator A5015010143 @default.
• W3175602039 creator A5060239336 @default.
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• W3175602039 date "2021-08-01" @default.
• W3175602039 modified "2023-10-14" @default.
• W3175602039 title "A micro-extrusion 3D printing platform for fabrication of orodispersible printlets for pediatric use" @default.
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• W3175602039 doi "https://doi.org/10.1016/j.ijpharm.2021.120854" @default.
• W3175602039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34224841" @default.
• W3175602039 hasPublicationYear "2021" @default.
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