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- W3175610665 abstract "Abstract Background Systemic effects of altered serum copper processing in Wilson Disease (WD) might induce myocardial copper deposition and consequently myocardial dysfunction and structural remodeling. This study sought to investigate the prevalence, manifestation and predictors of myocardial tissue abnormalities in WD patients. Methods We prospectively enrolled WD patients and an age-matched group of healthy individuals. We applied cardiovascular magnetic resonance (CMR) to analyze myocardial function, strain, and tissue characteristics. A subgroup analysis of WD patients with predominant neurological (WD-neuro + ) or hepatic manifestation only (WD-neuro − ) was performed. Results Seventy-six patients (37 years (27–49), 47% women) with known WD and 76 age-matched healthy control subjects were studied. The prevalence of atrial fibrillation in WD patients was 5% and the prevalence of symptomatic heart failure was 2.6%. Compared to healthy controls, patients with WD had a reduced left ventricular global circumferential strain (LV-GCS), and also showed abnormalities consistent with global and regional myocardial fibrosis. WD-neuro + patients presented with more severe structural remodeling and functional impairment when compared to WD-neuro − patients. Conclusions In a large cohort, WD was not linked to a distinct cardiac phenotype except CMR indexes of myocardial fibrosis. More research is warranted to assess the prognostic implications of these findings. Trial registration: This trial is registered at the local institutional ethics committee (S-188/2018)." @default.
- W3175610665 created "2021-07-05" @default.
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- W3175610665 date "2021-06-24" @default.
- W3175610665 modified "2023-10-14" @default.
- W3175610665 title "The impact of Wilson disease on myocardial tissue and function: a cardiovascular magnetic resonance study" @default.
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- W3175610665 cites W1983094838 @default.
- W3175610665 cites W1987655062 @default.
- W3175610665 cites W1992886088 @default.
- W3175610665 cites W1996610030 @default.
- W3175610665 cites W1998161078 @default.
- W3175610665 cites W1998818560 @default.
- W3175610665 cites W2002451854 @default.
- W3175610665 cites W2025321071 @default.
- W3175610665 cites W2037557484 @default.
- W3175610665 cites W2039057919 @default.
- W3175610665 cites W2054186815 @default.
- W3175610665 cites W2054698148 @default.
- W3175610665 cites W2066728152 @default.
- W3175610665 cites W2069412152 @default.
- W3175610665 cites W2069918539 @default.
- W3175610665 cites W2079522949 @default.
- W3175610665 cites W2079915102 @default.
- W3175610665 cites W2082997321 @default.
- W3175610665 cites W2100625171 @default.
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- W3175610665 cites W2129655528 @default.
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- W3175610665 cites W2137164176 @default.
- W3175610665 cites W2137166082 @default.
- W3175610665 cites W2141399496 @default.
- W3175610665 cites W2142429049 @default.
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- W3175610665 cites W2744278888 @default.
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- W3175610665 cites W2754894345 @default.
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- W3175610665 doi "https://doi.org/10.1186/s12968-021-00760-1" @default.
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