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- W3175627350 abstract "Oxidative stress caused by exposure to reactive oxygen species (ROS) induces widespread damage within the cell. ROS have damaging effects on the structure of DNA, proteins, and lipids, which contributes to the pathology of numerous diseases such as Parkinson's, Alzheimer's, and cancer. Cellular stress response mechanisms serve to mitigate the effects of oxidative stress by using antioxidant compounds to neutralize ROS. Black chokeberry (Aronia melanocarpa) is considered to be an excellent source of antioxidants such as polyphenols, anthocyanins and pro-anthocyanins. The aim of this study was to investigate whether a crude mixture of Aronia extract would increase lifespan and stress resistance in Caenorhabditis elegans. N2 Bristol strain survival and stress resistance were tested with toxicity (0 mg×mL−1, 0.1 mg×mL−1, 1 mg×mL−1, 5 mg×mL−1, and 10 mg×mL−1, A. melanocarpa) and heat stress assays. Supplementation with 0.1 mg×mL−1 Aronia significantly increased survival as compared to the control condition (p = 0.006). No significant difference in survival was observed with Aronia supplementation during heat stress (p = 0.27). In conclusion, these data suggested Aronia supplementation had a beneficial effect on worm survival. However, more research is necessary to determine its effect on survival and resistance in response to cellular heat stress. Support or Funding Information New investigator start-up, McNair Scholar Program This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal." @default.
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- W3175627350 date "2018-04-01" @default.
- W3175627350 modified "2023-09-26" @default.
- W3175627350 title "Effect of Aronia melanocarpa Extract on Lifespan and Stress Resistance in C. elegans" @default.
- W3175627350 doi "https://doi.org/10.1096/fasebj.2018.32.1_supplement.lb378" @default.
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