Matches in SemOpenAlex for { <https://semopenalex.org/work/W3175667946> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W3175667946 abstract "Stimulation of the type I angiotensin receptor (AT1R), can lead to activation of small G proteins, such as Ras. In the present study, we investigated the effect of angiotensin II (AngII) on intracellular Ras activity in living HEK293 cells expressing AT1 receptors, using bioluminescence resonance energy transfer (BRET) biosensors. In order to investigate the subcellular localization of AngII-induced Ras activation, we targeted the probes to various intracellular compartments, such as the TGN, the ER and early endosomes. We detected AngII-induced Ras activation in the TGN and the ER, but not in endosomes. In cells expressing a tail-deletion mutant AT1 receptor the AngII-induced response was enhanced, suggesting that receptor internalization and arrestin binding are not required for AngII-induced Ras activation in endomembranes. AngII was unable to stimulate Ras activity in the studied compartments in cells expressing the G protein coupling deficient mutant AT1 receptor. The presented data suggest that AngII can stimulate Ras activity in the TGN and the ER with a G protein dependently, which does not require arrestin-binding, receptor internalization and EGF receptor transactivation." @default.
- W3175667946 created "2021-07-05" @default.
- W3175667946 creator A5010688747 @default.
- W3175667946 creator A5026539610 @default.
- W3175667946 creator A5029096111 @default.
- W3175667946 creator A5042675661 @default.
- W3175667946 creator A5046786768 @default.
- W3175667946 date "2011-04-01" @default.
- W3175667946 modified "2023-10-17" @default.
- W3175667946 title "Detection of angiotensin II‐induced Ras activation in the trans‐Golgi network and the endoplasmic reticulum using BRET‐based biosensors" @default.
- W3175667946 doi "https://doi.org/10.1096/fasebj.25.1_supplement.lb131" @default.
- W3175667946 hasPublicationYear "2011" @default.
- W3175667946 type Work @default.
- W3175667946 sameAs 3175667946 @default.
- W3175667946 citedByCount "0" @default.
- W3175667946 crossrefType "journal-article" @default.
- W3175667946 hasAuthorship W3175667946A5010688747 @default.
- W3175667946 hasAuthorship W3175667946A5026539610 @default.
- W3175667946 hasAuthorship W3175667946A5029096111 @default.
- W3175667946 hasAuthorship W3175667946A5042675661 @default.
- W3175667946 hasAuthorship W3175667946A5046786768 @default.
- W3175667946 hasConcept C102747710 @default.
- W3175667946 hasConcept C119062480 @default.
- W3175667946 hasConcept C123915805 @default.
- W3175667946 hasConcept C135285700 @default.
- W3175667946 hasConcept C139770010 @default.
- W3175667946 hasConcept C158617107 @default.
- W3175667946 hasConcept C170493617 @default.
- W3175667946 hasConcept C174510640 @default.
- W3175667946 hasConcept C185592680 @default.
- W3175667946 hasConcept C2908929049 @default.
- W3175667946 hasConcept C55493867 @default.
- W3175667946 hasConcept C62478195 @default.
- W3175667946 hasConcept C79879829 @default.
- W3175667946 hasConcept C86803240 @default.
- W3175667946 hasConcept C95444343 @default.
- W3175667946 hasConceptScore W3175667946C102747710 @default.
- W3175667946 hasConceptScore W3175667946C119062480 @default.
- W3175667946 hasConceptScore W3175667946C123915805 @default.
- W3175667946 hasConceptScore W3175667946C135285700 @default.
- W3175667946 hasConceptScore W3175667946C139770010 @default.
- W3175667946 hasConceptScore W3175667946C158617107 @default.
- W3175667946 hasConceptScore W3175667946C170493617 @default.
- W3175667946 hasConceptScore W3175667946C174510640 @default.
- W3175667946 hasConceptScore W3175667946C185592680 @default.
- W3175667946 hasConceptScore W3175667946C2908929049 @default.
- W3175667946 hasConceptScore W3175667946C55493867 @default.
- W3175667946 hasConceptScore W3175667946C62478195 @default.
- W3175667946 hasConceptScore W3175667946C79879829 @default.
- W3175667946 hasConceptScore W3175667946C86803240 @default.
- W3175667946 hasConceptScore W3175667946C95444343 @default.
- W3175667946 hasIssue "S1" @default.
- W3175667946 hasLocation W31756679461 @default.
- W3175667946 hasOpenAccess W3175667946 @default.
- W3175667946 hasPrimaryLocation W31756679461 @default.
- W3175667946 hasRelatedWork W1498784784 @default.
- W3175667946 hasRelatedWork W1991265168 @default.
- W3175667946 hasRelatedWork W2045641731 @default.
- W3175667946 hasRelatedWork W2063599511 @default.
- W3175667946 hasRelatedWork W2084428565 @default.
- W3175667946 hasRelatedWork W2093037443 @default.
- W3175667946 hasRelatedWork W2131785177 @default.
- W3175667946 hasRelatedWork W3175071354 @default.
- W3175667946 hasRelatedWork W4256506521 @default.
- W3175667946 hasRelatedWork W4313131802 @default.
- W3175667946 hasVolume "25" @default.
- W3175667946 isParatext "false" @default.
- W3175667946 isRetracted "false" @default.
- W3175667946 magId "3175667946" @default.
- W3175667946 workType "article" @default.