FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3175676976> ?p ?o ?g. }

• W3175676976 endingPage "416" @default.
• W3175676976 startingPage "408" @default.
• W3175676976 abstract "The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is anticipated to transition to an endemic state as vaccines are providing relief in some, but not all, countries. Drug discovery for COVID-19 can offer another tool in the fight against the pandemic. Additionally, COVID-19 impacts multiple organs that call for a systems medicine approach to planetary health and therapeutics innovation. In this context, innovation for drugs that prevent and treat COVID-19 is timely and much needed. As the virus variants emerge under different ecological conditions and contexts in the long haul, a broad array of vaccine and drug options will be necessary. This expert review article argues for a need to expand the COVID-19 interventions, including and beyond vaccines, to stimulate discovery and development of novel medicines against SARS-CoV-2 infection. The Renin-Angiotensin-Aldosterone System (RAAS) is known to play a major role in SARS-CoV-2 infection. Neprilysin (NEP) and angiotensin-converting enzyme (ACE) have emerged as the pharmaceutical targets of interest in the search for therapeutic interventions against COVID-19. While the NEP/ACE inhibitors offer promise for repurposing against COVID-19, they may display a multitude of effects in different organ systems, some beneficial, and others adverse, in modulating the inflammation responses in the course of COVID-19. This expert review offers an analysis and discussion to deepen our present understanding of the pathophysiological function of neprilysin in multiple organs, and the possible effects of NEP inhibitor-induced inflammatory responses in COVID-19-infected patients." @default.
• W3175676976 created "2021-07-05" @default.
• W3175676976 creator A5064765384 @default.
• W3175676976 creator A5077073377 @default.
• W3175676976 creator A5090489290 @default.
• W3175676976 creator A5091014499 @default.
• W3175676976 date "2021-07-01" @default.
• W3175676976 modified "2023-10-06" @default.
• W3175676976 title "Broadening COVID-19 Interventions to Drug Innovation: Neprilysin Pathway as a Friend, Foe, or Promising Molecular Target?" @default.
• W3175676976 cites W1543111690 @default.
• W3175676976 cites W1545907965 @default.
• W3175676976 cites W1555309153 @default.
• W3175676976 cites W1636022800 @default.
• W3175676976 cites W1967467967 @default.
• W3175676976 cites W1970320081 @default.
• W3175676976 cites W1972565866 @default.
• W3175676976 cites W1974183132 @default.
• W3175676976 cites W1979912064 @default.
• W3175676976 cites W1981700814 @default.
• W3175676976 cites W1995132859 @default.
• W3175676976 cites W1998208719 @default.
• W3175676976 cites W2000181720 @default.
• W3175676976 cites W2013001343 @default.
• W3175676976 cites W2013860488 @default.
• W3175676976 cites W2016085424 @default.
• W3175676976 cites W2021212968 @default.
• W3175676976 cites W2035238376 @default.
• W3175676976 cites W2037060708 @default.
• W3175676976 cites W2040119967 @default.
• W3175676976 cites W2046699664 @default.
• W3175676976 cites W2052182309 @default.
• W3175676976 cites W2053533485 @default.
• W3175676976 cites W2056194845 @default.
• W3175676976 cites W2063924458 @default.
• W3175676976 cites W2073364218 @default.
• W3175676976 cites W2075919386 @default.
• W3175676976 cites W2082031851 @default.
• W3175676976 cites W2087580975 @default.
• W3175676976 cites W2089311308 @default.
• W3175676976 cites W2092788481 @default.
• W3175676976 cites W2094784974 @default.
• W3175676976 cites W2095727654 @default.
• W3175676976 cites W2105149323 @default.
• W3175676976 cites W2106398910 @default.
• W3175676976 cites W2109980291 @default.
• W3175676976 cites W2113698123 @default.
• W3175676976 cites W2117983251 @default.
• W3175676976 cites W2119569728 @default.
• W3175676976 cites W2120183098 @default.
• W3175676976 cites W2124664054 @default.
• W3175676976 cites W2125720205 @default.
• W3175676976 cites W2129337589 @default.
• W3175676976 cites W2153966730 @default.
• W3175676976 cites W2172244737 @default.
• W3175676976 cites W2215212915 @default.
• W3175676976 cites W2266772364 @default.
• W3175676976 cites W2285606889 @default.
• W3175676976 cites W2345025767 @default.
• W3175676976 cites W2424704070 @default.
• W3175676976 cites W2475677373 @default.
• W3175676976 cites W2513538639 @default.
• W3175676976 cites W2562411701 @default.
• W3175676976 cites W2732767128 @default.
• W3175676976 cites W2736856718 @default.
• W3175676976 cites W2890618895 @default.
• W3175676976 cites W2904992990 @default.
• W3175676976 cites W2940478411 @default.
• W3175676976 cites W2947020276 @default.
• W3175676976 cites W2969600050 @default.
• W3175676976 cites W2974541320 @default.
• W3175676976 cites W3001118548 @default.
• W3175676976 cites W3003464757 @default.
• W3175676976 cites W3007940623 @default.
• W3175676976 cites W3008827533 @default.
• W3175676976 cites W3009885589 @default.
• W3175676976 cites W3011755245 @default.
• W3175676976 cites W3012421327 @default.
• W3175676976 cites W3012515447 @default.
• W3175676976 cites W3012747666 @default.
• W3175676976 cites W3013231340 @default.
• W3175676976 cites W3013800395 @default.
• W3175676976 cites W3014571869 @default.
• W3175676976 cites W3014892190 @default.
• W3175676976 cites W3015925195 @default.
• W3175676976 cites W3016176352 @default.
• W3175676976 cites W3016636971 @default.
• W3175676976 cites W3017441365 @default.
• W3175676976 cites W3020423761 @default.
• W3175676976 cites W3020443288 @default.
• W3175676976 cites W3021543475 @default.
• W3175676976 cites W3022120179 @default.
• W3175676976 cites W3025670734 @default.
• W3175676976 cites W3030871984 @default.
• W3175676976 cites W3033797004 @default.
• W3175676976 cites W3034370534 @default.
• W3175676976 cites W3034437525 @default.
• W3175676976 cites W3036103215 @default.
• W3175676976 cites W3036811182 @default.

• next