FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3175686925> ?p ?o ?g. }

• W3175686925 abstract "Introduction Cerebral autoregulation (CA) maintains cerebral blood flow (CBF) despite changes in arterial blood pressure (ABP). However, CA has been shown to be frequency-dependent: Slow-frequency ABP oscillations are buffered, while rapid changes in ABP may be transmitted to the cerebral circulation. This may be clinically relevant, as mechanical ventilation during hypovolemia can induce oscillations in ABP. Our objective was to investigate whether CBF is maintained when ABP oscillates at respiratory frequency. Methods In eight healthy subjects (3 males), median age 21 yrs (range 19–29), rapid cyclical variations in ABP were generated by oscillatory lower body negative pressure (LBNPosc). The LBNP was changed from 0 to −30 mmHg within 0.5 s, oscillating at the individual subject's respiratory frequency, which was maintained by metronome breathing. Start of inspiration coincided with onset of LBNP, while chamber pressure was normalized during expiration. Beat-by-beat blood velocity in the right internal carotid artery (ICA) was measured by Doppler ultrasound (5 MHz, Vingmed SD-100, GE). ICA beat volume (ICA BV) was calculated using right internal carotid artery diameter measured at normovolemia by B-mode ultrasound. Non-invasive finger ABP was recorded continuously from the right middle finger (Finometer), providing beat-to-beat mean arterial pressure (MAP) and estimated beat-to-beat cardiac stroke volume (SV). Heart rate (HR, ECG), respiratory frequency (respiration belt), and end□tidal CO2 (ETCO2, capnography) were also recorded. The study was approved by the regional ethics committee and conformed to the Declaration of Helsinki. MAP variability (MAPV) and ICA beat volume variability (ICA BVV) were calculated by spectral analysis. Results are medians and 95% confidence intervals calculated by Hodges-Lehmann's estimates. Wilcoxon signed rank sum test for paired samples was used to test differences between conditions. P<0.05 was considered significant. Preliminary results MAPV increased significantly from 1.18 mmHg2 (0.55; 1.59) at baseline to 4.81 mmHg2 (2.8; 7.4) during LBNPosc (p=0.01). Median MAP barely decreased [baseline: 70 mmHg (62; 83), LBNPosc: 68 mmHg (58; 82), p=0.02], while SV, HR, and ETCO2 remained unchanged. Median ICA BV decreased by 10% (−19.7; −2.1) from baseline [6.7 ml (5.3; 8.2)] to LBNPosc [6 ml (4.8; 6.9), p=0.04]. ICA BVV was not significantly changed [from 0.07 ml2 (0.04; 0.18) to 0.14 ml2 (0.05; 0.29)], however coherence between MAPV and ICA BVV was high [0.6 (0.43; 0.76)] at LBNPosc, and significantly increased from baseline [0.32 (0.2; 0.56), p=0.01]. Conclusions Oscillatory LBNP at respiratory frequency increased MAPV markedly, while the change in MAP was very small. ICA BV decreased by 10% during oscillations in MAP. Coherence between MAPV and ICA BVV was high during LBNPosc. Thus, the buffering capacity of the CA may be outpaced during rapid variations in ABP, resulting in CBF not being maintained. This might have clinical implications for cerebral perfusion in hypovolemic patients undergoing mechanical ventilation. Support or Funding Information RCN and UiO This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal." @default.
• W3175686925 created "2021-07-05" @default.
• W3175686925 creator A5011093850 @default.
• W3175686925 creator A5040625487 @default.
• W3175686925 creator A5048623750 @default.
• W3175686925 creator A5084067477 @default.
• W3175686925 creator A5088146834 @default.
• W3175686925 date "2019-04-01" @default.
• W3175686925 modified "2023-09-27" @default.
• W3175686925 title "Cerebral Autoregulation Fails to Maintain Cerebral Blood Flow During Arterial Blood Pressure Oscillations at Respiratory Frequency" @default.
• W3175686925 doi "https://doi.org/10.1096/fasebj.2019.33.1_supplement.855.2" @default.
• W3175686925 hasPublicationYear "2019" @default.
• W3175686925 type Work @default.
• W3175686925 sameAs 3175686925 @default.
• W3175686925 citedByCount "0" @default.
• W3175686925 crossrefType "journal-article" @default.
• W3175686925 hasAuthorship W3175686925A5011093850 @default.
• W3175686925 hasAuthorship W3175686925A5040625487 @default.
• W3175686925 hasAuthorship W3175686925A5048623750 @default.
• W3175686925 hasAuthorship W3175686925A5084067477 @default.
• W3175686925 hasAuthorship W3175686925A5088146834 @default.
• W3175686925 hasConcept C111774379 @default.
• W3175686925 hasConcept C126322002 @default.
• W3175686925 hasConcept C157767197 @default.
• W3175686925 hasConcept C164705383 @default.
• W3175686925 hasConcept C191616109 @default.
• W3175686925 hasConcept C2775841333 @default.
• W3175686925 hasConcept C2777953023 @default.
• W3175686925 hasConcept C42219234 @default.
• W3175686925 hasConcept C541997718 @default.
• W3175686925 hasConcept C71924100 @default.
• W3175686925 hasConcept C8213797 @default.
• W3175686925 hasConcept C84359808 @default.
• W3175686925 hasConcept C84393581 @default.
• W3175686925 hasConceptScore W3175686925C111774379 @default.
• W3175686925 hasConceptScore W3175686925C126322002 @default.
• W3175686925 hasConceptScore W3175686925C157767197 @default.
• W3175686925 hasConceptScore W3175686925C164705383 @default.
• W3175686925 hasConceptScore W3175686925C191616109 @default.
• W3175686925 hasConceptScore W3175686925C2775841333 @default.
• W3175686925 hasConceptScore W3175686925C2777953023 @default.
• W3175686925 hasConceptScore W3175686925C42219234 @default.
• W3175686925 hasConceptScore W3175686925C541997718 @default.
• W3175686925 hasConceptScore W3175686925C71924100 @default.
• W3175686925 hasConceptScore W3175686925C8213797 @default.
• W3175686925 hasConceptScore W3175686925C84359808 @default.
• W3175686925 hasConceptScore W3175686925C84393581 @default.
• W3175686925 hasFunder F4320323260 @default.
• W3175686925 hasIssue "S1" @default.
• W3175686925 hasLocation W31756869251 @default.
• W3175686925 hasOpenAccess W3175686925 @default.
• W3175686925 hasPrimaryLocation W31756869251 @default.
• W3175686925 hasRelatedWork W1517815325 @default.
• W3175686925 hasRelatedWork W1964665860 @default.
• W3175686925 hasRelatedWork W1967111656 @default.
• W3175686925 hasRelatedWork W1996930938 @default.
• W3175686925 hasRelatedWork W2006809475 @default.
• W3175686925 hasRelatedWork W2012128758 @default.
• W3175686925 hasRelatedWork W2160651139 @default.
• W3175686925 hasRelatedWork W2418026908 @default.
• W3175686925 hasRelatedWork W3136876934 @default.
• W3175686925 hasRelatedWork W3217416559 @default.
• W3175686925 hasVolume "33" @default.
• W3175686925 isParatext "false" @default.
• W3175686925 isRetracted "false" @default.
• W3175686925 magId "3175686925" @default.
• W3175686925 workType "article" @default.