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- W3175715498 abstract "Abstract Genomic stability in proliferating cells critically depends on telomere maintenance by telomerase reverse transcriptase. Here we developed a real-time single-molecule RNA sequencing approach that visualizes telomerase catalysis and structural dynamics at single-nucleotide resolution using FRET and zero-mode waveguides. The method permits direct detection of dynamic steps and structural states throughout the telomerase catalytic cycle and can be generalized to other nucleic acid polymerase systems." @default.
- W3175715498 created "2021-07-05" @default.
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- W3175715498 date "2021-06-25" @default.
- W3175715498 modified "2023-09-24" @default.
- W3175715498 title "Multiplexed single-molecule analysis of human telomerase synthesizing DNA" @default.
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- W3175715498 doi "https://doi.org/10.1101/2021.06.25.449954" @default.
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