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- W3175742007 abstract "Abstract Continual improvements of diagnosis and treatment methods for malignant tumors have improved the survival rates of cancer patients, and treatment strategy for the cancer survivors should be discussed more carefully. The risk and prognosis of secondary primary malignancy (SPM) in the non-Hodgkin's lymphomas (NHLs) have been investigated intensively, while little is known about the clinical and prognostic impacts of the past history of cancer: past cancer (PC) and the co-existence of synchronous cancer (SC) in the treatment of NHLs. In this study, we retrospectively analyzed 809 patients with diffuse large B-cell lymphoma (DLBCL) who were histologically diagnosed and treated between January 2006 and February 2016 at seven independent institutes involved in the Kyoto Clinical Hematology Study Group (KOTOSG), and investigated the frequency and clinical impacts of PC and SC in DLBCL. Based on the Surveillance Epidemiology and End Results Program (SEER) definition for the chronicity of malignant tumors, DLBCL with PC was defined as patients with precedent cancer(s) that occurred more than two months before the diagnosis of DLBCL, DLBCL with SC was defined as patients diagnosed with lymphoma and other malignancies within two months, and DLBCL with MPM was defined as patients including both DLBCL with PC and DLBCL with SC. As the result, 123 (15.2%) of 809 DLBCL patients were defined as patients with MPM, including patients with PC (n=94) and patients with SC (n=29). The median age of DLBCL with MPM was statistically higher than that of patients without MPM (75 vs. 70 years old; p 5%) included gastric cancer (29.2%), colorectal (20.3%), prostate (12.2%), breast (12.2%), lung cancer (8.1%) and bladder cancer (5.7%). Stomach cancer was the most frequent in both PC and SC, and approximately two thirds (65.5%) of concomitant cancers were those detected by upper gastrointestinal survey, i.e., stomach cancer and upper aerodigestive tract cancer, in SC. We next investigated the prognostic impact of MPM. Importantly, both OS and PFS of DLBCL with MPM were significantly shorter than those without MPM (the 3-year OS: 56.2% vs. 74.6%, p Disclosures No relevant conflicts of interest to declare." @default.
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- W3175742007 date "2017-12-08" @default.
- W3175742007 modified "2023-09-29" @default.
- W3175742007 title "Prognostic Impact of Past History of Other Malignancies in Diffuse Large B Cell Lymphoma" @default.
- W3175742007 doi "https://doi.org/10.1182/blood.v130.suppl_1.1570.1570" @default.
- W3175742007 hasPublicationYear "2017" @default.
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