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• W3175804909 abstract "Melanoma cells have been shown to undergo fast amoeboid (leader bleb-based) migration, requiring a single large bleb for migration. In leader blebs, is a rapid flow of cortical actin that drives the cell forward. Using RNAi, we find that co-depleting cofilin-1 and actin depolymerizing factor (ADF) led to a large increase in cortical actin, suggesting that both proteins regulate cortical actin. Furthermore, severing factors can promote contractility through the regulation of actin architecture. However, RNAi of cofilin-1 but not ADF led to a significant decrease in cell stiffness. We found cofilin-1 to be enriched at leader bleb necks, whereas RNAi of cofilin-1 and ADF reduced bleb sizes and the frequency of motile cells. Strikingly, cells without cofilin-1 and ADF had blebs with abnormally long necks. Many of these blebs failed to retract and displayed slow actin turnover. Collectively, our data identifies cofilin-1 and ADF as actin remodeling factors required for fast amoeboid migration." @default.
• W3175804909 created "2021-07-05" @default.
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• W3175804909 date "2021-06-25" @default.
• W3175804909 modified "2023-10-01" @default.
• W3175804909 title "ADF and cofilin-1 collaborate to promote cortical actin flow and the leader bleb-based migration of confined cells" @default.
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• W3175804909 doi "https://doi.org/10.7554/elife.67856" @default.
• W3175804909 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8253594" @default.
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