FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3175807592> ?p ?o ?g. }

• W3175807592 abstract "Biomarkers are needed for patient stratification between benign thyroid nodules (BTN) and thyroid cancer (TC) and identifying metastasis in TC. Though plasma N-glycome profiling has shown potential in the discovery of biomarkers and can provide new insight into the mechanisms involved, little is known about it in TC and BTN. Besides, several studies have indicated associations between abnormal glycosylation and TC. Here, we aimed to explore plasma protein N-glycome of a TC cohort with regard to their applicability to serve as biomarkers.Plasma protein N-glycomes of TC, BTN, and matched healthy controls (HC) were obtained using a robust quantitative strategy based on MALDI-TOF MS and included linkage-specific sialylation information.Plasma N-glycans were found to differ between BTN, TC, and HC in main glycosylation features, namely complexity, galactosylation, fucosylation, and sialylation. Four altered glycan traits, which were consecutively decreased in BTN and TC, and classification models based on them showed high potential as biomarkers for discrimination between BTN and TC (moderately accurate to accurate). Additionally, strong associations were found between plasma N-glycans and lymph node metastasis in TC, which added the accuracy of predicting metastasis before surgery to the existing method.We comprehensively evaluated the plasma N-glycomic changes in patients with TC or BTN for the first time. We determined several N-glycan biomarkers, some of them have potential in the differential diagnosis of TC, and the others can help to stratify TC patients to low or high risk of lymph node metastasis. The findings enhanced the understanding of TC." @default.
• W3175807592 created "2021-07-05" @default.
• W3175807592 creator A5006982147 @default.
• W3175807592 creator A5022702230 @default.
• W3175807592 creator A5025273590 @default.
• W3175807592 creator A5030604432 @default.
• W3175807592 creator A5054839125 @default.
• W3175807592 date "2021-06-25" @default.
• W3175807592 modified "2023-10-14" @default.
• W3175807592 title "Distinguishing Benign and Malignant Thyroid Nodules and Identifying Lymph Node Metastasis in Papillary Thyroid Cancer by Plasma N-Glycomics" @default.
• W3175807592 cites W145329232 @default.
• W3175807592 cites W1971152739 @default.
• W3175807592 cites W1976484683 @default.
• W3175807592 cites W1984135618 @default.
• W3175807592 cites W1988112437 @default.
• W3175807592 cites W1989312956 @default.
• W3175807592 cites W2018042261 @default.
• W3175807592 cites W2028156774 @default.
• W3175807592 cites W2050663885 @default.
• W3175807592 cites W2050989163 @default.
• W3175807592 cites W2055099322 @default.
• W3175807592 cites W2068339549 @default.
• W3175807592 cites W2068713367 @default.
• W3175807592 cites W2068980146 @default.
• W3175807592 cites W2077963729 @default.
• W3175807592 cites W2079529928 @default.
• W3175807592 cites W2088999944 @default.
• W3175807592 cites W2090072034 @default.
• W3175807592 cites W2093010205 @default.
• W3175807592 cites W2115809142 @default.
• W3175807592 cites W2124268404 @default.
• W3175807592 cites W2131243337 @default.
• W3175807592 cites W2145150141 @default.
• W3175807592 cites W2159255202 @default.
• W3175807592 cites W2172179018 @default.
• W3175807592 cites W2201931892 @default.
• W3175807592 cites W2238271553 @default.
• W3175807592 cites W2317030694 @default.
• W3175807592 cites W2321180610 @default.
• W3175807592 cites W2328865493 @default.
• W3175807592 cites W2341832347 @default.
• W3175807592 cites W2520247616 @default.
• W3175807592 cites W2560742112 @default.
• W3175807592 cites W2588433986 @default.
• W3175807592 cites W2737546672 @default.
• W3175807592 cites W2743116197 @default.
• W3175807592 cites W2766740020 @default.
• W3175807592 cites W2789538733 @default.
• W3175807592 cites W2803366168 @default.
• W3175807592 cites W2803897372 @default.
• W3175807592 cites W2884004932 @default.
• W3175807592 cites W2887601262 @default.
• W3175807592 cites W2887824788 @default.
• W3175807592 cites W2889646458 @default.
• W3175807592 cites W2914562651 @default.
• W3175807592 cites W2920126023 @default.
• W3175807592 cites W2964407930 @default.
• W3175807592 cites W2969085274 @default.
• W3175807592 cites W2969726961 @default.
• W3175807592 cites W2993342086 @default.
• W3175807592 cites W2995547056 @default.
• W3175807592 cites W3005807756 @default.
• W3175807592 cites W3029166023 @default.
• W3175807592 cites W3037783644 @default.
• W3175807592 cites W3043919669 @default.
• W3175807592 cites W3084272520 @default.
• W3175807592 cites W4211213741 @default.
• W3175807592 cites W4322700657 @default.
• W3175807592 doi "https://doi.org/10.3389/fendo.2021.692910" @default.
• W3175807592 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8267918" @default.
• W3175807592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34248851" @default.
• W3175807592 hasPublicationYear "2021" @default.
• W3175807592 type Work @default.
• W3175807592 sameAs 3175807592 @default.
• W3175807592 citedByCount "9" @default.
• W3175807592 countsByYear W31758075922022 @default.
• W3175807592 countsByYear W31758075922023 @default.
• W3175807592 crossrefType "journal-article" @default.
• W3175807592 hasAuthorship W3175807592A5006982147 @default.
• W3175807592 hasAuthorship W3175807592A5022702230 @default.
• W3175807592 hasAuthorship W3175807592A5025273590 @default.
• W3175807592 hasAuthorship W3175807592A5030604432 @default.
• W3175807592 hasAuthorship W3175807592A5054839125 @default.
• W3175807592 hasBestOaLocation W31758075921 @default.
• W3175807592 hasConcept C106686826 @default.
• W3175807592 hasConcept C108625454 @default.
• W3175807592 hasConcept C121608353 @default.
• W3175807592 hasConcept C126322002 @default.
• W3175807592 hasConcept C142724271 @default.
• W3175807592 hasConcept C143998085 @default.
• W3175807592 hasConcept C158650290 @default.
• W3175807592 hasConcept C206212055 @default.
• W3175807592 hasConcept C2779013556 @default.
• W3175807592 hasConcept C2779022025 @default.
• W3175807592 hasConcept C2779212266 @default.
• W3175807592 hasConcept C2779761222 @default.
• W3175807592 hasConcept C2781197716 @default.
• W3175807592 hasConcept C502942594 @default.
• W3175807592 hasConcept C526584372 @default.
• W3175807592 hasConcept C55493867 @default.

• next