Matches in SemOpenAlex for { <https://semopenalex.org/work/W3175873749> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W3175873749 abstract "We tested the hypothesis that inhibiting interleukin-1β (IL-1β) with neutralizing monoclonal antibody (mAb) alters tight junction (TJ) protein expression after brain ischemia-reperfusion (I/R) in the ovine fetus. Ovine fetuses at 85% gestation were studied after 30 min of ischemia and 24 h of reperfusion. Ovine IL-1β mAb has been generated, and showed high sensitivity, specificity, and neutralizing effects to IL-1β protein in vitro. Intravenous placebo (PL) or IL-1β mAb (5 mg/kg) infusions were given to the fetuses 15 min and 4 h after brain ischemia. Occludin (Occl), claudin-1 (CL-1), and CL-5 protein expression were determined by Western immunoblot in non-ischemic (sham, n=5), I/R+PL (n=6), and I/R+IL-1β mAb-treated (n=7) groups in the cerebral cortex, caudate nucleus, cerebellum, and medulla. Results are expressed as ratio to an internal control protein. In the medulla, Occl expression decreased and CL-5 expression increased after I/R+IL-1β mAb treatment compared to the sham group (Fig., M ± SD, P<0.05), but CL-1 expression did not change. Similar patterns of TJ expression were not observed in the cerebral cortex, cerebellum or caudate nucleus (data not shown). Treatment with IL-1β mAb affects I/R-related transmembrane TJ protein expression in some, but not all brain regions studied. Alterations in BBB function after I/R and IL-1β mAb treatment may not be directly regulated by changes in transmembrane TJ proteins in the fetus. NIH-HD-057100" @default.
- W3175873749 created "2021-07-05" @default.
- W3175873749 creator A5011689741 @default.
- W3175873749 creator A5025733362 @default.
- W3175873749 creator A5058192036 @default.
- W3175873749 creator A5064007757 @default.
- W3175873749 creator A5064810678 @default.
- W3175873749 creator A5085820276 @default.
- W3175873749 date "2012-04-01" @default.
- W3175873749 modified "2023-09-27" @default.
- W3175873749 title "Effect of Inhibiting Interleukin‐1β with Neutralizing Antibody on Tight Junction Protein Expression after Brain Ischemia in Ovine Fetus" @default.
- W3175873749 doi "https://doi.org/10.1096/fasebj.26.1_supplement.707.2" @default.
- W3175873749 hasPublicationYear "2012" @default.
- W3175873749 type Work @default.
- W3175873749 sameAs 3175873749 @default.
- W3175873749 citedByCount "0" @default.
- W3175873749 crossrefType "journal-article" @default.
- W3175873749 hasAuthorship W3175873749A5011689741 @default.
- W3175873749 hasAuthorship W3175873749A5025733362 @default.
- W3175873749 hasAuthorship W3175873749A5058192036 @default.
- W3175873749 hasAuthorship W3175873749A5064007757 @default.
- W3175873749 hasAuthorship W3175873749A5064810678 @default.
- W3175873749 hasAuthorship W3175873749A5085820276 @default.
- W3175873749 hasConcept C126322002 @default.
- W3175873749 hasConcept C159654299 @default.
- W3175873749 hasConcept C16685009 @default.
- W3175873749 hasConcept C172680121 @default.
- W3175873749 hasConcept C203014093 @default.
- W3175873749 hasConcept C2779234561 @default.
- W3175873749 hasConcept C2779261636 @default.
- W3175873749 hasConcept C541997718 @default.
- W3175873749 hasConcept C54355233 @default.
- W3175873749 hasConcept C71924100 @default.
- W3175873749 hasConcept C86803240 @default.
- W3175873749 hasConceptScore W3175873749C126322002 @default.
- W3175873749 hasConceptScore W3175873749C159654299 @default.
- W3175873749 hasConceptScore W3175873749C16685009 @default.
- W3175873749 hasConceptScore W3175873749C172680121 @default.
- W3175873749 hasConceptScore W3175873749C203014093 @default.
- W3175873749 hasConceptScore W3175873749C2779234561 @default.
- W3175873749 hasConceptScore W3175873749C2779261636 @default.
- W3175873749 hasConceptScore W3175873749C541997718 @default.
- W3175873749 hasConceptScore W3175873749C54355233 @default.
- W3175873749 hasConceptScore W3175873749C71924100 @default.
- W3175873749 hasConceptScore W3175873749C86803240 @default.
- W3175873749 hasIssue "S1" @default.
- W3175873749 hasLocation W31758737491 @default.
- W3175873749 hasOpenAccess W3175873749 @default.
- W3175873749 hasPrimaryLocation W31758737491 @default.
- W3175873749 hasRelatedWork W2352641992 @default.
- W3175873749 hasRelatedWork W2363693236 @default.
- W3175873749 hasRelatedWork W2373402090 @default.
- W3175873749 hasRelatedWork W2394372752 @default.
- W3175873749 hasRelatedWork W3164921642 @default.
- W3175873749 hasRelatedWork W3208004137 @default.
- W3175873749 hasRelatedWork W4280568907 @default.
- W3175873749 hasRelatedWork W4294953459 @default.
- W3175873749 hasRelatedWork W4310873631 @default.
- W3175873749 hasRelatedWork W4313308281 @default.
- W3175873749 hasVolume "26" @default.
- W3175873749 isParatext "false" @default.
- W3175873749 isRetracted "false" @default.
- W3175873749 magId "3175873749" @default.
- W3175873749 workType "article" @default.