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• W3175894013 abstract "Herein we report the nickel-catalyzed reductive dicarbofunctionalization of 1,1-disubstituted enamides with unactivated alkyl iodides to access the 3,3-dialkyl-substituted isoindolinone frameworks. This tandem cyclization/reductive coupling protocol exhibits broad functional group tolerance under mild conditions. The utilization of commercially accessible chiral Bn-Biox ligand allows excellent enantioselectivities to forge the tetrasubstituted stereocenters." @default.
• W3175894013 created "2021-07-05" @default.
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• W3175894013 date "2021-06-28" @default.
• W3175894013 modified "2023-10-04" @default.
• W3175894013 title "Synthesis of 3,3-Dialkyl-Substituted Isoindolinones Enabled by Nickel-Catalyzed Reductive Dicarbofunctionalization of Enamides" @default.
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• W3175894013 doi "https://doi.org/10.1021/acs.orglett.1c01871" @default.
• W3175894013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34181428" @default.
• W3175894013 hasPublicationYear "2021" @default.
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