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- W3175969158 abstract "Myeloperoxidase (MPO) is a leukocyte-derived heme protein. Recent studies suggest that MPO may be a mediator of leukocyte-induced vascular injury responses. In order to understand the possible role of MPO in vascular remodeling, we tested its effects on neointimal hyperplasia after angioplasty. Carotid artery balloon injury was performed in 90 male Sprague-Dawley rats (250–300 g) and MPO levels in balloon injured versus uninjured control arteries were measured. MPO levels significantly increased in balloon-injured arteries compared to uninjured arteries [n=9; p<0.001 compared to control group (n=9)]. Inhibition of endogenous MPO levels and/or activities via blockade of MPO infiltration (n=12), leukocyte depletion (n=12), or MPO inhibitors (n=9) decreased neointima formation after angioplasty [p<0.01, compared to vehicle control group (n=12)]. In addition, exogenous MPO increased neointima formation [n=12; p<0.01 compared to vehicle control group (n=12)]. Our results also show that MPO-induced neointima formation is accompanied by decreased nitric oxide bioavailability and increased activation of mitogen-activated protein (MAP) kinases, P38 and ERK1/2. In conclusion, the present findings suggest an important role for leukocyte-derived MPO in neointimal hyperplasia after angioplasty and this event appears to be mediated by down-regulation of nitric oxide bioavailability and up-regulation of MAP kinases. Blockade of the MPO activity may be a novel therapeutic approach to attenuating restenosis after balloon angioplasty" @default.
- W3175969158 created "2021-07-05" @default.
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- W3175969158 date "2006-03-01" @default.
- W3175969158 modified "2023-10-16" @default.
- W3175969158 title "A novel role for leukocyte‐derived myeloperoxidase in neointimal hyperplasia after angioplasty" @default.
- W3175969158 doi "https://doi.org/10.1096/fasebj.20.4.a728" @default.
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