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• W3176004939 abstract "Treatment of Splenic (SMZL) and Nodal (NMZL) Marginal Zone Lymphoma is not consensual. Histologic transformation (HT) to aggressive lymphoma is a poorly understood event, with an unfavorable outcome.Describe the clinical characteristics, treatment, outcomes and incidence of HT.Characteristics of patients with SMZL and NMZL consecutively diagnosed in 8 Portuguese centers were retrospectively reviewed. Endpoints were overall survival (OS), time to first systemic treatment (TTFST), frequency of HT and time to transformation (TTT).This study included 122 SMZL and 68 NMZL, most of them received systemic treatment: 55.4% and 76.5%, respectively. Splenectomy was performed in 58.7% of patients with SMZL. Different treatment protocols were used. OS or TTFST did not differ significantly according to treatments. Given the small sample size, no conclusion can be made concerning the role of Rituximab in the treatment of NMZL and SMZL based in these results. HT was documented in 18 patients, mainly in SMZL, with a cumulative incidence at 5 years of 4.2%. We confirmed that age is a prognostic factor.Randomized prospective trials are needed to standardize treatment in MZL. Patients with HT did appear to have shorter OS in comparison with those who did not experience HT (OS 5 years of 68.4% vs. 80.4%), but the number of HT was too small to reach statistical significance." @default.
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• W3176004939 date "2021-11-01" @default.
• W3176004939 modified "2023-10-01" @default.
• W3176004939 title "Clinical Characteristics, Treatment and Evolution of Splenic and Nodal Marginal Zone Lymphomas—Retrospective and Multicentric Analysis of Portuguese Centers" @default.
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• W3176004939 doi "https://doi.org/10.1016/j.clml.2021.06.013" @default.
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