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• W3176133050 startingPage "3974" @default.
• W3176133050 abstract "Histone deacetylase enzymes (HDACs) are potential targets for the treatment of cancer and other diseases, but it is challenging to design isoform-selective agents. In this work, we created new analogs of two established but non-selective HDAC inhibitors. We decorated the central linker chains of the molecules with specifically positioned fluorine atoms in order to control the molecular conformations. The fluorinated analogs were screened against a panel of 11 HDAC isoforms, and minor differences in isoform selectivity patterns were observed." @default.
• W3176133050 created "2021-07-05" @default.
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• W3176133050 date "2021-06-29" @default.
• W3176133050 modified "2023-09-25" @default.
• W3176133050 title "The Effect of Vicinal Difluorination on the Conformation and Potency of Histone Deacetylase Inhibitors" @default.
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• W3176133050 doi "https://doi.org/10.3390/molecules26133974" @default.
• W3176133050 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8271401" @default.
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