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- W3176134088 abstract "2,3,5-Tris-(glutathion-S-yl)hydroquinone (TGHQ) is a nephrocarcinogen in the Eker rat, predisposed to renal tumors by a mutation in one allele (Tsc-2EK/+) of the tuberous sclerosis tumor suppressor, Tsc-2, gene. In the present study, both Tsc-2+/+ (wild-type) and Tsc-2EK/+ (mutant) rats were treated with TGHQ (i.p.) for 1–8 months. TGHQ induced cell proliferation in the kidney in the outer stripe of the outer medulla region in both Tsc-2+/+ and Tsc-2EK/+ rats, but only induced tumors in Tsc-2EK/+ rats. TGHQ increased transcription (cDNA microarray) and expression (immunohistochemistry, IHC) of annexin I and II (AI & AII) in injured cells (Tsc-2+/+ and Tsc-2EK/+) and preneoplastic lesions and renal tumors (Tsc-2EK/+). AII appeared in the cytoplasm in injured cells and the membrane in pre- and neoplastic cells, suggesting movement from the cytoplasm to membranes during compensatory proliferation following cell injury. MALDI-TOF mass spectral imaging of rat kidney slices from a TGHQ treated (8 mo) Tsc-2EK/+ and an untreated Tsc-2+/+ rat revealed the same distribution of AI and II as seen with IHC. Moreover an increase in mono- and bisphosphorylated AI and AII were detected in TGHQ treated Tsc-2EK/+ rats by MS-based tissue imaging technique. The role of native and post-translationally modified AI and AII in TGHQ-induced cell injury, cell proliferation and tumor formation is under investigation (GM39338, P30ES06694)." @default.
- W3176134088 created "2021-07-05" @default.
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- W3176134088 date "2006-03-01" @default.
- W3176134088 modified "2023-09-26" @default.
- W3176134088 title "Immuohistochemical and MALDI Imaging Reveal Changes in Expression and Phosphorylation of Annexin I and II in Chemical‐Induced Renal Tumors" @default.
- W3176134088 doi "https://doi.org/10.1096/fasebj.20.4.a66-a" @default.
- W3176134088 hasPublicationYear "2006" @default.
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