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- W3176142503 abstract "Epithelial tissues are lined with a sheet-like basement membrane (BM) extracellular matrix at their basal surfaces that plays essential roles in adhesion and signaling. BMs also provide mechanical support to guide morphogenesis. Despite their importance, we know little about how epithelial cells secrete and assemble BMs during development. BM proteins are sorted into a basolateral secretory pathway distinct from other basolateral proteins. Because BM proteins self-assemble into networks and the BM lines only a small portion of the basolateral domain, we hypothesized that the site of BM protein secretion might be tightly controlled. Using the Drosophila follicular epithelium, we show that kinesin-3 and kinesin-1 motors work together to define this secretion site. Like all epithelia, the follicle cells have a polarized microtubule (MT) array along their apical-basal axes. Since these cells collectively migrate, they also have a polarized MT array along the migratory axis at the basal surface. We find these two MT arrays are interconnected, which allows kinesins to transport Rab10+ BM secretory vesicles both basally and to the trailing edge of each cell. This positions them near the basal surface and the basal-most region of the lateral domain for exocytosis. When kinesin transport is disrupted, the site of BM protein secretion is expanded, and ectopic BM networks form between cells that impede migration and disrupt tissue architecture. These results show how epithelial cells can define a subdomain on their basolateral surface through MT-based transport and highlight the importance of controlling the exocytic site of network-forming proteins." @default.
- W3176142503 created "2021-07-05" @default.
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- W3176142503 creator A5084383648 @default.
- W3176142503 date "2021-01-01" @default.
- W3176142503 modified "2023-09-23" @default.
- W3176142503 title "Basement Membrane Protein Secretion is Directed to a Basal Region of the Basolateral Membrane in Epithelial Cells by Kinesin-3 and Kinesin-1 Motors" @default.
- W3176142503 doi "https://doi.org/10.2139/ssrn.3834684" @default.
- W3176142503 hasPublicationYear "2021" @default.
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