Matches in SemOpenAlex for { <https://semopenalex.org/work/W3176172021> ?p ?o ?g. }
- W3176172021 endingPage "65" @default.
- W3176172021 startingPage "56" @default.
- W3176172021 abstract "ELAV-like protein 1 or HuR (human antigen R) is an RNA-binding protein that in humans is encoded by the ELAVL1 gene, and one of its best functions is to stabilize mRNAs in order to regulate gene expression. HuR protein overexpression has undoubtedly been linked to an increased risk of tumor growth, progression and metastasis, rendering it a potential therapeutic target candidate in cancer. Novel agents, interfering with HuR expression, have been tested, both in vitro and in vivo, with promising results. The aim of this paper is to review the existing literature regarding the potential agents that could actively act on and inhibit HuR expression. HuR molecule controls the expression of various proto-oncogenes, cytokines and growth factors, representing a major player in tumor progression, invasion and metastasis and constituting an emerging target for cancer therapy. PubMed database was thoroughly searched, and all published articles providing scientific data on molecules that can exhibit antitumorigenic effects via HuR inhibition were included. According to these data, HuR inhibition should be a promising target in cancer therapeutics." @default.
- W3176172021 created "2021-07-05" @default.
- W3176172021 creator A5006412575 @default.
- W3176172021 creator A5007928274 @default.
- W3176172021 creator A5067307920 @default.
- W3176172021 creator A5075736993 @default.
- W3176172021 date "2022-01-01" @default.
- W3176172021 modified "2023-10-13" @default.
- W3176172021 title "HuR as Therapeutic Target in Cancer: What the Future Holds" @default.
- W3176172021 cites W1872005043 @default.
- W3176172021 cites W1898679165 @default.
- W3176172021 cites W1964805922 @default.
- W3176172021 cites W1965882417 @default.
- W3176172021 cites W1981781176 @default.
- W3176172021 cites W1984423977 @default.
- W3176172021 cites W1993841930 @default.
- W3176172021 cites W1995567920 @default.
- W3176172021 cites W2001453032 @default.
- W3176172021 cites W2008374869 @default.
- W3176172021 cites W2015175027 @default.
- W3176172021 cites W2019928317 @default.
- W3176172021 cites W2033300742 @default.
- W3176172021 cites W2037009541 @default.
- W3176172021 cites W2039041285 @default.
- W3176172021 cites W2046100110 @default.
- W3176172021 cites W2054630268 @default.
- W3176172021 cites W2059628427 @default.
- W3176172021 cites W2059796196 @default.
- W3176172021 cites W2073531417 @default.
- W3176172021 cites W2076232466 @default.
- W3176172021 cites W2090703970 @default.
- W3176172021 cites W2091132171 @default.
- W3176172021 cites W2092104932 @default.
- W3176172021 cites W2095609506 @default.
- W3176172021 cites W2110439394 @default.
- W3176172021 cites W2111685937 @default.
- W3176172021 cites W2115794627 @default.
- W3176172021 cites W2123737072 @default.
- W3176172021 cites W2125524603 @default.
- W3176172021 cites W2127243900 @default.
- W3176172021 cites W2129849942 @default.
- W3176172021 cites W2133590393 @default.
- W3176172021 cites W2142496066 @default.
- W3176172021 cites W2149480306 @default.
- W3176172021 cites W2162674813 @default.
- W3176172021 cites W2170120455 @default.
- W3176172021 cites W2260872739 @default.
- W3176172021 cites W2411413825 @default.
- W3176172021 cites W2418255697 @default.
- W3176172021 cites W2521390122 @default.
- W3176172021 cites W2605818487 @default.
- W3176172021 cites W2621066222 @default.
- W3176172021 cites W2734989022 @default.
- W3176172021 cites W2738272913 @default.
- W3176172021 cites W2745356508 @default.
- W3176172021 cites W2748564011 @default.
- W3176172021 cites W2769260650 @default.
- W3176172021 cites W2769280193 @default.
- W3176172021 cites W2783890003 @default.
- W3176172021 cites W2785516826 @default.
- W3176172021 cites W2900738255 @default.
- W3176172021 cites W2914106589 @default.
- W3176172021 cites W2950418164 @default.
- W3176172021 cites W2995329150 @default.
- W3176172021 cites W3020127841 @default.
- W3176172021 cites W35524438 @default.
- W3176172021 doi "https://doi.org/10.2174/0929867328666210628143430" @default.
- W3176172021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34182901" @default.
- W3176172021 hasPublicationYear "2022" @default.
- W3176172021 type Work @default.
- W3176172021 sameAs 3176172021 @default.
- W3176172021 citedByCount "12" @default.
- W3176172021 countsByYear W31761720212021 @default.
- W3176172021 countsByYear W31761720212022 @default.
- W3176172021 countsByYear W31761720212023 @default.
- W3176172021 crossrefType "journal-article" @default.
- W3176172021 hasAuthorship W3176172021A5006412575 @default.
- W3176172021 hasAuthorship W3176172021A5007928274 @default.
- W3176172021 hasAuthorship W3176172021A5067307920 @default.
- W3176172021 hasAuthorship W3176172021A5075736993 @default.
- W3176172021 hasConcept C104317684 @default.
- W3176172021 hasConcept C121608353 @default.
- W3176172021 hasConcept C150194340 @default.
- W3176172021 hasConcept C207001950 @default.
- W3176172021 hasConcept C22615655 @default.
- W3176172021 hasConcept C2779013556 @default.
- W3176172021 hasConcept C502942594 @default.
- W3176172021 hasConcept C54355233 @default.
- W3176172021 hasConcept C60644358 @default.
- W3176172021 hasConcept C67705224 @default.
- W3176172021 hasConcept C70721500 @default.
- W3176172021 hasConcept C86803240 @default.
- W3176172021 hasConcept C96232424 @default.
- W3176172021 hasConceptScore W3176172021C104317684 @default.
- W3176172021 hasConceptScore W3176172021C121608353 @default.
- W3176172021 hasConceptScore W3176172021C150194340 @default.
- W3176172021 hasConceptScore W3176172021C207001950 @default.
- W3176172021 hasConceptScore W3176172021C22615655 @default.