Matches in SemOpenAlex for { <https://semopenalex.org/work/W3176196625> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W3176196625 abstract "The cerebrovasculature uniquely autoregulates flow in the face of changing pressure. The static curve established that cerebral autoregulation is nonlinear, encompassing a region where pressure changes are counterregulated, and outside of which pressure induces parallel flow changes. Recent work has shown low coherence (i.e., frequency specific linear correlation) between pressure and flow fluctuations, indicating a ‘dynamic’ autoregulation. However, low coherence also evidences insufficiency in linear analyses - absence of correlation prohibits assessment of autoregulatory function. Therefore, I applied a nonparametric projection pursuit regression to extract the dominant nonlinearity within cerebral flow response to pressure fluctuations. Data was obtained from 48 volunteers during oscillatory lower body negative pressure (30–40 mmHg) at 6 frequencies (0.03–0.08 Hz). The regression explained the majority of flow changes at all frequencies and provided a nonlinearity that was consistent across all individuals and that diminished at higher frequencies (Figure). This characteristic nonlinearity accounts for low coherence and suggests that dynamic autoregulation simply may reflect a ‘faster’ static function. Thus, a robust yet simple nonlinear approach can enhance our integrative understanding of cerebral autoregulatory control. Supported by NIH grant HL093113." @default.
- W3176196625 created "2021-07-05" @default.
- W3176196625 creator A5013531627 @default.
- W3176196625 date "2012-04-01" @default.
- W3176196625 modified "2023-09-23" @default.
- W3176196625 title "Defining cerebral autoregulation: is dynamic simply faster static?" @default.
- W3176196625 doi "https://doi.org/10.1096/fasebj.26.1_supplement.685.28" @default.
- W3176196625 hasPublicationYear "2012" @default.
- W3176196625 type Work @default.
- W3176196625 sameAs 3176196625 @default.
- W3176196625 citedByCount "1" @default.
- W3176196625 countsByYear W31761966252018 @default.
- W3176196625 crossrefType "journal-article" @default.
- W3176196625 hasAuthorship W3176196625A5013531627 @default.
- W3176196625 hasConcept C102366305 @default.
- W3176196625 hasConcept C105795698 @default.
- W3176196625 hasConcept C111774379 @default.
- W3176196625 hasConcept C117220453 @default.
- W3176196625 hasConcept C117251300 @default.
- W3176196625 hasConcept C121332964 @default.
- W3176196625 hasConcept C126322002 @default.
- W3176196625 hasConcept C154945302 @default.
- W3176196625 hasConcept C15744967 @default.
- W3176196625 hasConcept C158622935 @default.
- W3176196625 hasConcept C2524010 @default.
- W3176196625 hasConcept C2775924081 @default.
- W3176196625 hasConcept C2781181686 @default.
- W3176196625 hasConcept C33923547 @default.
- W3176196625 hasConcept C38349280 @default.
- W3176196625 hasConcept C41008148 @default.
- W3176196625 hasConcept C47446073 @default.
- W3176196625 hasConcept C57879066 @default.
- W3176196625 hasConcept C62520636 @default.
- W3176196625 hasConcept C71924100 @default.
- W3176196625 hasConcept C84359808 @default.
- W3176196625 hasConcept C84393581 @default.
- W3176196625 hasConceptScore W3176196625C102366305 @default.
- W3176196625 hasConceptScore W3176196625C105795698 @default.
- W3176196625 hasConceptScore W3176196625C111774379 @default.
- W3176196625 hasConceptScore W3176196625C117220453 @default.
- W3176196625 hasConceptScore W3176196625C117251300 @default.
- W3176196625 hasConceptScore W3176196625C121332964 @default.
- W3176196625 hasConceptScore W3176196625C126322002 @default.
- W3176196625 hasConceptScore W3176196625C154945302 @default.
- W3176196625 hasConceptScore W3176196625C15744967 @default.
- W3176196625 hasConceptScore W3176196625C158622935 @default.
- W3176196625 hasConceptScore W3176196625C2524010 @default.
- W3176196625 hasConceptScore W3176196625C2775924081 @default.
- W3176196625 hasConceptScore W3176196625C2781181686 @default.
- W3176196625 hasConceptScore W3176196625C33923547 @default.
- W3176196625 hasConceptScore W3176196625C38349280 @default.
- W3176196625 hasConceptScore W3176196625C41008148 @default.
- W3176196625 hasConceptScore W3176196625C47446073 @default.
- W3176196625 hasConceptScore W3176196625C57879066 @default.
- W3176196625 hasConceptScore W3176196625C62520636 @default.
- W3176196625 hasConceptScore W3176196625C71924100 @default.
- W3176196625 hasConceptScore W3176196625C84359808 @default.
- W3176196625 hasConceptScore W3176196625C84393581 @default.
- W3176196625 hasFunder F4320332161 @default.
- W3176196625 hasIssue "S1" @default.
- W3176196625 hasLocation W31761966251 @default.
- W3176196625 hasOpenAccess W3176196625 @default.
- W3176196625 hasPrimaryLocation W31761966251 @default.
- W3176196625 hasRelatedWork W1509121458 @default.
- W3176196625 hasRelatedWork W1984121182 @default.
- W3176196625 hasRelatedWork W1990900551 @default.
- W3176196625 hasRelatedWork W2040235734 @default.
- W3176196625 hasRelatedWork W2089765282 @default.
- W3176196625 hasRelatedWork W2125745248 @default.
- W3176196625 hasRelatedWork W2367526667 @default.
- W3176196625 hasRelatedWork W2415367889 @default.
- W3176196625 hasRelatedWork W2989608694 @default.
- W3176196625 hasRelatedWork W1796221433 @default.
- W3176196625 hasVolume "26" @default.
- W3176196625 isParatext "false" @default.
- W3176196625 isRetracted "false" @default.
- W3176196625 magId "3176196625" @default.
- W3176196625 workType "article" @default.