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- W3176201863 abstract "Associated with actin cytoskeletal rearrangements, cellular migration, and cellular invasion, Phospholipase D (PLD) has been implicated in the formation of tumors. The signaling relationship between PLD and ERK is inconsistent, with several reports of PLD activity described upstream, downstream or not involved with ERK activation. We report here that 50 μM phenylephrine (PE), a specific α1-adrenergic receptor agonist, can activate PLD through a growth factor pathway and that inhibition of phosphatidic acid by butanol addition blocks PE stimulation of ERK. We further show that blocking PLD activity by using primary alcohols or expressing catalytically inactive forms of PLD1 and PLD2 results in the inhibition of cellular migration events, including stress fiber formation and wounding assays. A relationship between the activity of PLD and the sodium hydrogen exchanger will also be assessed. Finally, the metastatic potential caused by the combination of increased cytoskeletal contraction and enhanced directional migration will be measured using a soft agar invasion assay in cells expressing wild-type or catalytically inactive PLD1 or PLD2. These data suggest a role for PLD in the specific α1-adrenergic receptor signaling of cell events that may be critical for the invasive properties of non-muscle cells. This work was supported by a MSU Moorhead Faculty Grant, NIH-1-R15-HL074924-01A1, and NSF-MCB0080243" @default.
- W3176201863 created "2021-07-05" @default.
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- W3176201863 date "2006-03-01" @default.
- W3176201863 modified "2023-09-23" @default.
- W3176201863 title "Role of Phospholipase D in activation of the ERK, cell migration and cell invasion in Chinese hamster lung fibroblasts" @default.
- W3176201863 doi "https://doi.org/10.1096/fasebj.20.4.a485-d" @default.
- W3176201863 hasPublicationYear "2006" @default.
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