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• W3176209972 abstract "Spontaneous abortion is the most common complication of early pregnancy, affecting up to 20% of recognized pregnancies. Kisspeptin is predominantly released by placental syncytiotrophoblasts, and regulates their placental invasion into the uterine matrices. We aimed to establish an association of serum kisspeptin levels with pregnancy outcomes during the early gestational stage of the first trimester.In this prospective study, 90 pregnant women in their 7 to 8 6/7 gestational weeks were classified into three groups: (i) The control group, consisting of healthy pregnant women (n=30), (ii) the threatened abortion group (n=30), and (iii) the spontaneous abortion group (n=30). The maternal serum samples were analyzed for complete blood count parameters and kisspeptin levels.There was no statistical difference regarding body mass index (BMI) and gestational age (p=0.370). Regarding detailed obstetric notations, including gravida, parity, abortion, and living children, socioeconomic levels, and employment rates, all study groups were comparable (p>0.05, for all). No significant association was found regarding the biochemical parameters of complete blood count, including neutrophil, lymphocyte, and platelet concentrations, as well as neutrophil-to-lymphocyte ratios (NLR) and platelet-to-lymphocyte ratios (PLR) (p>0.05, for all). The median serum kisspeptin levels of the study groups did not differ between the groups (p=0.153). Correlation analysis revealed no significant relationship between serum kisspeptin levels and other study parameters in any study groups (p>0.05, for all).We found no statistically significant relationship between serum kisspeptin concentrations and pregnancy outcomes in the early gestational stage of the first trimester, and serum kisspeptin concentrations did not seem to be a reliable marker to distinguish abortion status from viable pregnancy.Spontan abortus, erken gebeliğin en sık görülen komplikasyonudur ve tanınan gebeliklerin % 20’sini etkilemektedir. Kisspeptin, plasental sinsitiyotrofoblastlar tarafından salınmakta olup rahim matrislerine plasental invazyonu düzenlemektedir. Biz bu çalışmada ilk trimesterin erken gebelik evresindeki gebelik sonuçları ile serum kisspeptin düzeyleri arasında bir ilişki kurmayı amaçladık.Bu prospektif çalışmada, 7-8 6/7 hafta gebelikleri olan doksan gebe toplam üç gruba ayrıldı: (i) sağlıklı gebelerden oluşan kontrol grubu (n=30), (ii) düşük tehdidi grubu (n=30) ve (iii) spontan düşük grubu (n=30). Maternal serum örnekleri, tam kan sayımı parametreleri ve kisspeptin seviyeleri analiz edildi.Vücut kütle indeksi ve gebelik yaşı açısından istatistiksel olarak fark yoktu (p=0.370). Gravida, parite, kürtaj ve yaşayan çocuklar, sosyo-ekonomik düzey ve istihdam dahil olmak üzere ayrıntılı obstetrik durumlarla ilgili olarak çalışma grupları arasında fark yoktu (p>0.05). Nötrofil, lenfosit ve trombosit sayılarının yanı sıra nötrofil-lenfosit oranı (NLR) ve trombosit-lenfosit oranı (PLR) dahil olmak üzere tam kan sayımının biyokimyasal parametreleri açısından önemli bir ilişki bulunmadı (p>0.05). Çalışma grupları arasında medyan serum kisspeptin seviyeleri anlamlı farklılık göstermedi (p=0.153). Korelasyon analiz testi tüm çalışma gruplarında kisspeptin ile diğer çalışma parametreleri arasında bir korelasyonun olmadığını gösterdi (p>0.05).Bulgularımız, birinci trimesterin erken gebelik evresinde serum kisspeptin konsantrasyonu ile gebelik sonuçları arasında herhangi bir ilişkinin olmadığını ve serum kisspeptin konsantrasyo-nunun düşük durumunu canlı gebeliklerden ayırt etmek için güvenilir bir belirteç olmadığını gös-termiştir." @default.
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• W3176209972 date "2021-01-01" @default.
• W3176209972 modified "2023-10-16" @default.
• W3176209972 title "Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions" @default.
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• W3176209972 doi "https://doi.org/10.5222/mmj.2021.32549" @default.
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