Matches in SemOpenAlex for { <https://semopenalex.org/work/W3176222790> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W3176222790 abstract "Homeostatic replenishment of endothelial cells (ECs) after injury is required for the efficient formation of a stable endothelial lineage and to prevent long-lasting lung vascular injury such as protein-rich edema in the interstitial tissue, a hallmark of tissue inflammation. However, mechanisms maintaining EC lineage remains unclear. Phosphatase and tensin homologue (PTEN), a tumor suppressor, is well-known to function in cell membrane to negatively regulate PIP3 levels required for angiogenesis and endothelial cell proliferation and thereby may have role in regulating EC fate. Thus, we induced the conditional deletion of PTEN in ECs of adult mice using tamoxifen to address the hypothesis that PTEN regulates EC lineage. Intriguingly, we found that EC-specific loss of PTEN led to intractable vascular injury basally due to marked reduction in EC number in the lung. FACS analysis showed that these ECs acquired fibroblast-like phenotype. RNA seq analysis of PTEN depleted ECs showed PTEN was required for maintaining ECs genes including VE-cadherin and PECAM. PTEN maintained ECs genes by activating ETS (E26 Transformation Specific) family member transcription factor, ERG. We show that this function of PTEN occur in nucleus since loss of PTEN increased the activity of epigenetic modulating gene, HDAC1 leading to upregulation of non-EC genes and thereby converting these ECs into fibroblasts like cells. Inhibition of HDAC1 activity by velproic acid and trichostatin rescued ERG expression and transcription of VE-cadherin in PTEN depleted cells. Thus, we identify a novel role of PTEN in suppressing HDAC1 activity enabling thereby ERG transcription of EC genes leading to EC generation and lung-vascular homeostasis. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal." @default.
- W3176222790 created "2021-07-05" @default.
- W3176222790 creator A5008207475 @default.
- W3176222790 creator A5009374037 @default.
- W3176222790 creator A5023321945 @default.
- W3176222790 creator A5030542659 @default.
- W3176222790 creator A5036650939 @default.
- W3176222790 creator A5087479152 @default.
- W3176222790 creator A5068093921 @default.
- W3176222790 date "2018-04-01" @default.
- W3176222790 modified "2023-09-27" @default.
- W3176222790 title "PTEN suppresses epigenetic modulation of ERG transcription factor to maintain endothelial lineage and vascular integrity" @default.
- W3176222790 doi "https://doi.org/10.1096/fasebj.2018.32.1_supplement.746.10" @default.
- W3176222790 hasPublicationYear "2018" @default.
- W3176222790 type Work @default.
- W3176222790 sameAs 3176222790 @default.
- W3176222790 citedByCount "0" @default.
- W3176222790 crossrefType "journal-article" @default.
- W3176222790 hasAuthorship W3176222790A5008207475 @default.
- W3176222790 hasAuthorship W3176222790A5009374037 @default.
- W3176222790 hasAuthorship W3176222790A5023321945 @default.
- W3176222790 hasAuthorship W3176222790A5030542659 @default.
- W3176222790 hasAuthorship W3176222790A5036650939 @default.
- W3176222790 hasAuthorship W3176222790A5068093921 @default.
- W3176222790 hasAuthorship W3176222790A5087479152 @default.
- W3176222790 hasBestOaLocation W31762227901 @default.
- W3176222790 hasConcept C104317684 @default.
- W3176222790 hasConcept C2777609662 @default.
- W3176222790 hasConcept C2779549131 @default.
- W3176222790 hasConcept C2780394083 @default.
- W3176222790 hasConcept C502942594 @default.
- W3176222790 hasConcept C54355233 @default.
- W3176222790 hasConcept C62478195 @default.
- W3176222790 hasConcept C86339819 @default.
- W3176222790 hasConcept C86554907 @default.
- W3176222790 hasConcept C86803240 @default.
- W3176222790 hasConcept C95444343 @default.
- W3176222790 hasConceptScore W3176222790C104317684 @default.
- W3176222790 hasConceptScore W3176222790C2777609662 @default.
- W3176222790 hasConceptScore W3176222790C2779549131 @default.
- W3176222790 hasConceptScore W3176222790C2780394083 @default.
- W3176222790 hasConceptScore W3176222790C502942594 @default.
- W3176222790 hasConceptScore W3176222790C54355233 @default.
- W3176222790 hasConceptScore W3176222790C62478195 @default.
- W3176222790 hasConceptScore W3176222790C86339819 @default.
- W3176222790 hasConceptScore W3176222790C86554907 @default.
- W3176222790 hasConceptScore W3176222790C86803240 @default.
- W3176222790 hasConceptScore W3176222790C95444343 @default.
- W3176222790 hasIssue "S1" @default.
- W3176222790 hasLocation W31762227901 @default.
- W3176222790 hasOpenAccess W3176222790 @default.
- W3176222790 hasPrimaryLocation W31762227901 @default.
- W3176222790 hasRelatedWork W1959848155 @default.
- W3176222790 hasRelatedWork W2057241633 @default.
- W3176222790 hasRelatedWork W2081467680 @default.
- W3176222790 hasRelatedWork W2143654068 @default.
- W3176222790 hasRelatedWork W2744966301 @default.
- W3176222790 hasRelatedWork W2900464141 @default.
- W3176222790 hasRelatedWork W4289705004 @default.
- W3176222790 hasRelatedWork W4319242539 @default.
- W3176222790 hasRelatedWork W4320006642 @default.
- W3176222790 hasRelatedWork W2522379078 @default.
- W3176222790 hasVolume "32" @default.
- W3176222790 isParatext "false" @default.
- W3176222790 isRetracted "false" @default.
- W3176222790 magId "3176222790" @default.
- W3176222790 workType "article" @default.