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- W3176236415 endingPage "10121" @default.
- W3176236415 startingPage "10106" @default.
- W3176236415 abstract "The Gram-negative bacillus Serratia marcescens, a member of Enterobacteriaceae family, is an opportunistic nosocomial pathogen commonly found in hospital outbreaks that can cause infections in the urinary tract, bloodstream, central nervous system and pneumonia. Because S. marcescens strains are resistant to several antibiotics, it is critical the need for effective treatments, including new drugs and vaccines. Here, we applied reverse vaccinology and subtractive genomic approaches for the in silico prediction of potential vaccine and drug targets against 59 strains of S. marcescens. We found 759 core non-host homologous proteins, of which 87 are putative surface-exposed proteins, 183 secreted proteins, and 80 membrane proteins. From these proteins, we predicted seven candidates vaccine targets: a sn-glycerol-3-phosphate-binding periplasmic protein UgpB, a vitamin B12 TonB-dependent receptor, a ferrichrome porin FhuA, a divisome-associated lipoprotein YraP, a membrane-bound lytic murein transglycosylase A, a peptidoglycan lytic exotransglycosylase, and a DUF481 domain-containing protein. We also predicted two drug targets: a N(4)-acetylcytidine amidohydrolase, and a DUF1428 family protein. Using the molecular docking approach for each drug target, we identified and selected ZINC04259491 and ZINC04235390 molecules as the most favorable interactions with the target active site residues. Our findings may contribute to the development of vaccines and new drug targets against S. marcescens. Communicated by Ramaswamy H. Sarma" @default.
- W3176236415 created "2021-07-05" @default.
- W3176236415 creator A5009349717 @default.
- W3176236415 creator A5017249124 @default.
- W3176236415 creator A5026465125 @default.
- W3176236415 creator A5027455398 @default.
- W3176236415 creator A5037565432 @default.
- W3176236415 creator A5042302781 @default.
- W3176236415 creator A5044908846 @default.
- W3176236415 creator A5056356335 @default.
- W3176236415 creator A5059674760 @default.
- W3176236415 creator A5067139143 @default.
- W3176236415 creator A5073361185 @default.
- W3176236415 creator A5090969979 @default.
- W3176236415 date "2021-06-30" @default.
- W3176236415 modified "2023-10-11" @default.
- W3176236415 title "New putative therapeutic targets against <i>Serratia marcescens</i> using reverse vaccinology and subtractive genomics" @default.
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