FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3176257029> ?p ?o ?g. }

• W3176257029 endingPage "117630" @default.
• W3176257029 startingPage "117630" @default.
• W3176257029 abstract "Bisphenol A (BPA) may induce oxidative stress as well as the toxicity of colon cancer cells. We hypothesized that BPA exposure and interactions with genetic variants might be associated with colorectal cancer (CRC) risk, and the association might be partly mediated by oxidative stress. We measured urinary BPA and three oxidative stress markers [8-iso-prostaglandinF 2α (8-isoPGF 2α ), 8-hydroxydeoxyguanosine (8-OHdG) and 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA)] in 275 new CRC cases and 538 healthy controls. A set of 25 genetic variations in 12 candidate DNA repair genes and 5 metabolic enzyme genes were genotyped by Sequenom MassARRAY approach. In multivariable logistic regression, significant positive associations of CRC risk with BPA, 8-OHdG and HNE-MA were observed. Additionally, 8-OHdG, HNE-MA and 8-isoPGF 2α were significantly positively associated with BPA ( P < 0.05). The mediation analysis showed BPA-associated HNE-MA significantly mediated 11.81% of the effect of BPA on CRC risk. Moreover, BPA was found to interact with ERCC5 rs17655 and rs2296147 (both P multiplicative < 0.05) to increase CRC risk. In brief, our results suggested BPA was associated with CRC risk and the positive association of BPA with CRC risk might be partly mediated by the oxidative stress HNE-MA. BPA might interact with ERCC5 rs17655 and rs2296147 to increase CRC risk. • Bisphenol A (BPA) was positively associated with three oxidative stress biomarkers and the risk of colorectal cancer. • Oxidative stress biomarker HNE-MA significantly mediated 11.81% of the effect of BPA on colorectal cancer risk. • BPA was found to interact with ERCC5 rs17655 and rs2296147 to increase colorectal cancer risk." @default.
• W3176257029 created "2021-07-05" @default.
• W3176257029 creator A5006101921 @default.
• W3176257029 creator A5020015820 @default.
• W3176257029 creator A5037219613 @default.
• W3176257029 creator A5046118417 @default.
• W3176257029 creator A5058481549 @default.
• W3176257029 creator A5063159905 @default.
• W3176257029 creator A5066586569 @default.
• W3176257029 creator A5074871313 @default.
• W3176257029 creator A5075809491 @default.
• W3176257029 creator A5078394815 @default.
• W3176257029 creator A5081814390 @default.
• W3176257029 date "2021-10-01" @default.
• W3176257029 modified "2023-10-17" @default.
• W3176257029 title "Bisphenol A exposure, interaction with genetic variants and colorectal cancer via mediating oxidative stress biomarkers" @default.
• W3176257029 cites W1633462988 @default.
• W3176257029 cites W1796063308 @default.
• W3176257029 cites W1969524738 @default.
• W3176257029 cites W1976950210 @default.
• W3176257029 cites W1982788880 @default.
• W3176257029 cites W1985274289 @default.
• W3176257029 cites W2014585392 @default.
• W3176257029 cites W2014776577 @default.
• W3176257029 cites W2019378745 @default.
• W3176257029 cites W2020383780 @default.
• W3176257029 cites W2086417754 @default.
• W3176257029 cites W2114647004 @default.
• W3176257029 cites W2115976071 @default.
• W3176257029 cites W2128721089 @default.
• W3176257029 cites W2135986822 @default.
• W3176257029 cites W2152196433 @default.
• W3176257029 cites W2164272712 @default.
• W3176257029 cites W2172046153 @default.
• W3176257029 cites W2586967350 @default.
• W3176257029 cites W2592606137 @default.
• W3176257029 cites W2621333085 @default.
• W3176257029 cites W2764242953 @default.
• W3176257029 cites W2765214566 @default.
• W3176257029 cites W2771580952 @default.
• W3176257029 cites W2787569430 @default.
• W3176257029 cites W2799690522 @default.
• W3176257029 cites W2884908197 @default.
• W3176257029 cites W2890697985 @default.
• W3176257029 cites W2904873151 @default.
• W3176257029 cites W2914084793 @default.
• W3176257029 cites W2921497398 @default.
• W3176257029 cites W2963919103 @default.
• W3176257029 cites W2981596557 @default.
• W3176257029 cites W2982418088 @default.
• W3176257029 cites W2991303641 @default.
• W3176257029 cites W2997158818 @default.
• W3176257029 cites W3000110067 @default.
• W3176257029 cites W3013751924 @default.
• W3176257029 cites W3027153771 @default.
• W3176257029 cites W3048777645 @default.
• W3176257029 cites W3102511407 @default.
• W3176257029 cites W3128646645 @default.
• W3176257029 cites W1985046539 @default.
• W3176257029 doi "https://doi.org/10.1016/j.envpol.2021.117630" @default.
• W3176257029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34182385" @default.
• W3176257029 hasPublicationYear "2021" @default.
• W3176257029 type Work @default.
• W3176257029 sameAs 3176257029 @default.
• W3176257029 citedByCount "9" @default.
• W3176257029 countsByYear W31762570292022 @default.
• W3176257029 countsByYear W31762570292023 @default.
• W3176257029 crossrefType "journal-article" @default.
• W3176257029 hasAuthorship W3176257029A5006101921 @default.
• W3176257029 hasAuthorship W3176257029A5020015820 @default.
• W3176257029 hasAuthorship W3176257029A5037219613 @default.
• W3176257029 hasAuthorship W3176257029A5046118417 @default.
• W3176257029 hasAuthorship W3176257029A5058481549 @default.
• W3176257029 hasAuthorship W3176257029A5063159905 @default.
• W3176257029 hasAuthorship W3176257029A5066586569 @default.
• W3176257029 hasAuthorship W3176257029A5074871313 @default.
• W3176257029 hasAuthorship W3176257029A5075809491 @default.
• W3176257029 hasAuthorship W3176257029A5078394815 @default.
• W3176257029 hasAuthorship W3176257029A5081814390 @default.
• W3176257029 hasConcept C121608353 @default.
• W3176257029 hasConcept C126322002 @default.
• W3176257029 hasConcept C134018914 @default.
• W3176257029 hasConcept C143998085 @default.
• W3176257029 hasConcept C2776151105 @default.
• W3176257029 hasConcept C2781197716 @default.
• W3176257029 hasConcept C502942594 @default.
• W3176257029 hasConcept C526805850 @default.
• W3176257029 hasConcept C54355233 @default.
• W3176257029 hasConcept C60644358 @default.
• W3176257029 hasConcept C71924100 @default.
• W3176257029 hasConcept C86803240 @default.
• W3176257029 hasConceptScore W3176257029C121608353 @default.
• W3176257029 hasConceptScore W3176257029C126322002 @default.
• W3176257029 hasConceptScore W3176257029C134018914 @default.
• W3176257029 hasConceptScore W3176257029C143998085 @default.
• W3176257029 hasConceptScore W3176257029C2776151105 @default.
• W3176257029 hasConceptScore W3176257029C2781197716 @default.
• W3176257029 hasConceptScore W3176257029C502942594 @default.

• next